Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space

IntroductionThe impact of spaceflight on the immune system and mitochondria has been investigated for decades. However, the molecular mechanisms underlying spaceflight-induced immune dysregulations are still unclear.MethodsIn this study, blood from eleven crewmembers was collected before and during...

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Bibliographic Details
Main Authors: Maria Moreno-Villanueva, Luis E. Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E. Pauken, Brian C. Schaefer, Brian E. Crucian, Honglu Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
spaceflight
transcriptomics
astronauts’ health
mitochondria
immune dysfunction
telomere lengthening
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1512578/full
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