Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections
A simple, sensitive, and exact methyl esterification in combination with gas chromatography-mass spectrometry (GC-MS) method was developed to determine the contents of palmitic acid and stearic acid in the chlorinated butyl rubber stoppers and liposome injections in order to evaluate the compatibili...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/9760580 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566113904361472 |
|---|---|
| author | Xun Gao Kexin Chen Miaomiao Chi Kunming Qin |
| author_facet | Xun Gao Kexin Chen Miaomiao Chi Kunming Qin |
| author_sort | Xun Gao |
| collection | DOAJ |
| description | A simple, sensitive, and exact methyl esterification in combination with gas chromatography-mass spectrometry (GC-MS) method was developed to determine the contents of palmitic acid and stearic acid in the chlorinated butyl rubber stoppers and liposome injections in order to evaluate the compatibility of pharmaceutical packaging materials. In this experiment, palmitic acid and stearic acid were detected in the form of methyl hexadecanoate and methyl stearate in chlorinated butyl rubber stoppers and liposome injections. The results showed good linearities in the range of 0.50–10.00 µg·mL−1 for methyl hexadecanoate and 1.00–20.00 µg·mL−1 for methyl stearate, with the limits of detection (LOD) 11.94 ng·mL−1 and 11.90 ng·mL−1, respectively. The recoveries that ranged from 95.25% to 100.29% were satisfied, and the relative standard deviation (RSD) was no more than 7.16%. The developed method was successfully applied to evaluate the compatibility of chlorinated butyl rubber stoppers with liposome injections and the safety assessment. |
| format | Article |
| id | doaj-art-15bbe5d38f8f48deb4062bccf9e33adc |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-15bbe5d38f8f48deb4062bccf9e33adc2025-02-03T01:05:04ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792020-01-01202010.1155/2020/97605809760580Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome InjectionsXun Gao0Kexin Chen1Miaomiao Chi2Kunming Qin3School of Pharmacy, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, 59 Cangwu Road Haizhou District, Lianyungang, Jiangsu, ChinaSchool of Pharmacy, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, 59 Cangwu Road Haizhou District, Lianyungang, Jiangsu, ChinaSchool of Pharmacy, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, 59 Cangwu Road Haizhou District, Lianyungang, Jiangsu, ChinaSchool of Pharmacy, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, 59 Cangwu Road Haizhou District, Lianyungang, Jiangsu, ChinaA simple, sensitive, and exact methyl esterification in combination with gas chromatography-mass spectrometry (GC-MS) method was developed to determine the contents of palmitic acid and stearic acid in the chlorinated butyl rubber stoppers and liposome injections in order to evaluate the compatibility of pharmaceutical packaging materials. In this experiment, palmitic acid and stearic acid were detected in the form of methyl hexadecanoate and methyl stearate in chlorinated butyl rubber stoppers and liposome injections. The results showed good linearities in the range of 0.50–10.00 µg·mL−1 for methyl hexadecanoate and 1.00–20.00 µg·mL−1 for methyl stearate, with the limits of detection (LOD) 11.94 ng·mL−1 and 11.90 ng·mL−1, respectively. The recoveries that ranged from 95.25% to 100.29% were satisfied, and the relative standard deviation (RSD) was no more than 7.16%. The developed method was successfully applied to evaluate the compatibility of chlorinated butyl rubber stoppers with liposome injections and the safety assessment.http://dx.doi.org/10.1155/2020/9760580 |
| spellingShingle | Xun Gao Kexin Chen Miaomiao Chi Kunming Qin Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections International Journal of Analytical Chemistry |
| title | Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections |
| title_full | Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections |
| title_fullStr | Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections |
| title_full_unstemmed | Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections |
| title_short | Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections |
| title_sort | methyl esterification combined with gas chromatography mass spectrometry gc ms for determining the contents of lubricant to evaluate the compatibility of chlorinated butyl rubber stoppers with liposome injections |
| url | http://dx.doi.org/10.1155/2020/9760580 |
| work_keys_str_mv | AT xungao methylesterificationcombinedwithgaschromatographymassspectrometrygcmsfordeterminingthecontentsoflubricanttoevaluatethecompatibilityofchlorinatedbutylrubberstopperswithliposomeinjections AT kexinchen methylesterificationcombinedwithgaschromatographymassspectrometrygcmsfordeterminingthecontentsoflubricanttoevaluatethecompatibilityofchlorinatedbutylrubberstopperswithliposomeinjections AT miaomiaochi methylesterificationcombinedwithgaschromatographymassspectrometrygcmsfordeterminingthecontentsoflubricanttoevaluatethecompatibilityofchlorinatedbutylrubberstopperswithliposomeinjections AT kunmingqin methylesterificationcombinedwithgaschromatographymassspectrometrygcmsfordeterminingthecontentsoflubricanttoevaluatethecompatibilityofchlorinatedbutylrubberstopperswithliposomeinjections |