Alternative Splicing: Emerging Roles in Anti-Aging Strategies
Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence. Significant changes to alternative splicing, including dysregulated splicing events and the abnormal expre...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/131 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588884296335360 |
|---|---|
| author | Lingyue Gao Rong Jia |
| author_facet | Lingyue Gao Rong Jia |
| author_sort | Lingyue Gao |
| collection | DOAJ |
| description | Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence. Significant changes to alternative splicing, including dysregulated splicing events and the abnormal expression of splicing factors, have been detected during the aging process or in age-related disorders. Here, we highlight the possibility of suppressing aging and cellular senescence by controlling alternative splicing. In this review, we will summarize the latest research progress on alternative splicing in aging and cellular senescence, discuss the roles and regulatory mechanisms of alternative splicing during aging, and then excavate existing and potential approaches to anti-aging by controlling alternative splicing. Novel therapeutic breakthroughs concerning aging and senescence entail a further understanding of regulating alternative splicing mechanically and accurately. |
| format | Article |
| id | doaj-art-15b2845e150a4006a2d8d55d5b151ada |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-15b2845e150a4006a2d8d55d5b151ada2025-01-24T13:25:18ZengMDPI AGBiomolecules2218-273X2025-01-0115113110.3390/biom15010131Alternative Splicing: Emerging Roles in Anti-Aging StrategiesLingyue Gao0Rong Jia1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430072, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430072, ChinaAlternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence. Significant changes to alternative splicing, including dysregulated splicing events and the abnormal expression of splicing factors, have been detected during the aging process or in age-related disorders. Here, we highlight the possibility of suppressing aging and cellular senescence by controlling alternative splicing. In this review, we will summarize the latest research progress on alternative splicing in aging and cellular senescence, discuss the roles and regulatory mechanisms of alternative splicing during aging, and then excavate existing and potential approaches to anti-aging by controlling alternative splicing. Novel therapeutic breakthroughs concerning aging and senescence entail a further understanding of regulating alternative splicing mechanically and accurately.https://www.mdpi.com/2218-273X/15/1/131alternative splicingagingsplicing factoranti-aging |
| spellingShingle | Lingyue Gao Rong Jia Alternative Splicing: Emerging Roles in Anti-Aging Strategies Biomolecules alternative splicing aging splicing factor anti-aging |
| title | Alternative Splicing: Emerging Roles in Anti-Aging Strategies |
| title_full | Alternative Splicing: Emerging Roles in Anti-Aging Strategies |
| title_fullStr | Alternative Splicing: Emerging Roles in Anti-Aging Strategies |
| title_full_unstemmed | Alternative Splicing: Emerging Roles in Anti-Aging Strategies |
| title_short | Alternative Splicing: Emerging Roles in Anti-Aging Strategies |
| title_sort | alternative splicing emerging roles in anti aging strategies |
| topic | alternative splicing aging splicing factor anti-aging |
| url | https://www.mdpi.com/2218-273X/15/1/131 |
| work_keys_str_mv | AT lingyuegao alternativesplicingemergingrolesinantiagingstrategies AT rongjia alternativesplicingemergingrolesinantiagingstrategies |