Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China
Objectives This study aimed to clarify the relationship between white blood cell (WBC) and adverse pregnancy outcomes.Design A total of 25 270 pregnant women underwent peripheral blood white blood cell count tests in the first, second and third trimesters. Adverse pregnancy outcomes were gestational...
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BMJ Publishing Group
2023-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/11/e072633.full |
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| author | Yu Zhang Xuesong Li Zheng Hu Yuping Song Yiling Qian Chuanwei Liu Xiaofang Fan Yujuan Fan Jialin Yang |
| author_facet | Yu Zhang Xuesong Li Zheng Hu Yuping Song Yiling Qian Chuanwei Liu Xiaofang Fan Yujuan Fan Jialin Yang |
| author_sort | Yu Zhang |
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| description | Objectives This study aimed to clarify the relationship between white blood cell (WBC) and adverse pregnancy outcomes.Design A total of 25 270 pregnant women underwent peripheral blood white blood cell count tests in the first, second and third trimesters. Adverse pregnancy outcomes were gestational hypertension, pre-eclampsia, gestational diabetes mellitus, preterm birth, low birth weight, caesarean delivery, macrosomia and fetal distress. Due to acute infectious disease or other diseases, 1127 were excluded.Setting Minhang Hospital, China.Participants A total of 24 143 pregnant women were included in this study.Primary and secondary outcome measures The primary outcome was the adverse pregnancy outcomes.Results For the 24 143 participants, we calculated adjusted ORs for adverse pregnancy outcomes associated with an increased WBC count. For gestational hypertension, the ORs were 1.18 (95% CI, 1.05 to 1.24) in the first trimester and 1.10 (1.06 to 1.13) in the second trimester; for pre-eclampsia, ORs were 1.14 (95% CI, 1.47 to 1.64) in the first trimester and 1.10 (1.05 to 1.16) in the second trimester; for gestational diabetes mellitus, ORs were 1.06 (95% CI, 1.00 to 1.13) in the first trimester and 1.10 (1.04 to 1.16) in the second trimester; for preterm birth, ORs were 1.12 (95% CI, 1.06 to 1.18) in the first trimester, 1.10 (1.06 to 1.13) in the second trimester and 1.12 (1.09 to 1.15) in the third trimester; for low birth weight, ORs were 1.09 (95% CI, 1.02 to 1.17) in the first trimester, 1.03 (0.99 to 1.08) in the second trimester and 1.12 (1.08 to 1.16) in the third trimester. Significant associations were not observed obviously for caesarean delivery, macrosomia and fetal distress.Conclusions Our results indicate strong, continuous associations of maternal WBC count with increased risks of adverse pregnancy outcomes. |
| format | Article |
| id | doaj-art-15b1cc220b2c49e68173d97f93deb1fd |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-15b1cc220b2c49e68173d97f93deb1fd2025-02-02T02:45:14ZengBMJ Publishing GroupBMJ Open2044-60552023-11-01131110.1136/bmjopen-2023-072633Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in ChinaYu Zhang0Xuesong Li1Zheng Hu2Yuping Song3Yiling Qian4Chuanwei Liu5Xiaofang Fan6Yujuan Fan7Jialin Yang8Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USADepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Minhang Hospital, Fudan University, Shanghai, ChinaObjectives This study aimed to clarify the relationship between white blood cell (WBC) and adverse pregnancy outcomes.Design A total of 25 270 pregnant women underwent peripheral blood white blood cell count tests in the first, second and third trimesters. Adverse pregnancy outcomes were gestational hypertension, pre-eclampsia, gestational diabetes mellitus, preterm birth, low birth weight, caesarean delivery, macrosomia and fetal distress. Due to acute infectious disease or other diseases, 1127 were excluded.Setting Minhang Hospital, China.Participants A total of 24 143 pregnant women were included in this study.Primary and secondary outcome measures The primary outcome was the adverse pregnancy outcomes.Results For the 24 143 participants, we calculated adjusted ORs for adverse pregnancy outcomes associated with an increased WBC count. For gestational hypertension, the ORs were 1.18 (95% CI, 1.05 to 1.24) in the first trimester and 1.10 (1.06 to 1.13) in the second trimester; for pre-eclampsia, ORs were 1.14 (95% CI, 1.47 to 1.64) in the first trimester and 1.10 (1.05 to 1.16) in the second trimester; for gestational diabetes mellitus, ORs were 1.06 (95% CI, 1.00 to 1.13) in the first trimester and 1.10 (1.04 to 1.16) in the second trimester; for preterm birth, ORs were 1.12 (95% CI, 1.06 to 1.18) in the first trimester, 1.10 (1.06 to 1.13) in the second trimester and 1.12 (1.09 to 1.15) in the third trimester; for low birth weight, ORs were 1.09 (95% CI, 1.02 to 1.17) in the first trimester, 1.03 (0.99 to 1.08) in the second trimester and 1.12 (1.08 to 1.16) in the third trimester. Significant associations were not observed obviously for caesarean delivery, macrosomia and fetal distress.Conclusions Our results indicate strong, continuous associations of maternal WBC count with increased risks of adverse pregnancy outcomes.https://bmjopen.bmj.com/content/13/11/e072633.full |
| spellingShingle | Yu Zhang Xuesong Li Zheng Hu Yuping Song Yiling Qian Chuanwei Liu Xiaofang Fan Yujuan Fan Jialin Yang Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China BMJ Open |
| title | Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China |
| title_full | Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China |
| title_fullStr | Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China |
| title_full_unstemmed | Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China |
| title_short | Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China |
| title_sort | association between white blood cell count and adverse pregnancy outcomes a retrospective cohort study from a tertiary hospital in china |
| url | https://bmjopen.bmj.com/content/13/11/e072633.full |
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