High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease
Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3795142 |
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| author | Maria Vittoria Arcidiacono Montserrat Martinez-Alonso Montserrat Belart Ana Vilar Marisa Martín Lourdes Craver Àngels Betriu Dídac Mauricio José Manuel Valdivielso Elvira Fernández Mercè Borràs |
| author_facet | Maria Vittoria Arcidiacono Montserrat Martinez-Alonso Montserrat Belart Ana Vilar Marisa Martín Lourdes Craver Àngels Betriu Dídac Mauricio José Manuel Valdivielso Elvira Fernández Mercè Borràs |
| author_sort | Maria Vittoria Arcidiacono |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefore, the aim of the study was to (1) evaluate if the carotid aVV in CKD patients increases in comparison to its physiological value of healthy patients; (2) explore which traditional or nontraditional risk factor including inflammation, bone and mineral metabolism, and anemia could be related to the aVV angiogenesis. CKD patients without previous cardiovascular events (44, stages 3-4; 37, stage 5D) and 65 healthy subjects were compared. The carotid aVV and the intima-media thickness (cIMT) were evaluated by ultrasound. CKD patients at stages 3-4 showed higher aVV of the right carotid artery even after adjusting for age. Importantly, a multiple linear regression model showed hemoglobin levels > 12.5 g/dL as the factor for an estimated higher aVV of the right carotid artery. In conclusion, the association of hemoglobin with higher aVV could suggest the role of high hemoglobin in the higher incidence of adverse cardiovascular outcomes in CKD patients. |
| format | Article |
| id | doaj-art-15b19579b60640a98bd35a78c5447e7e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-15b19579b60640a98bd35a78c5447e7e2025-02-03T06:08:09ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/37951423795142High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney DiseaseMaria Vittoria Arcidiacono0Montserrat Martinez-Alonso1Montserrat Belart2Ana Vilar3Marisa Martín4Lourdes Craver5Àngels Betriu6Dídac Mauricio7José Manuel Valdivielso8Elvira Fernández9Mercè Borràs10Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, ItalyStatistics Department, IRBLleida, Lleida, SpainSistemes Renals, Lleida, SpainDepartment of Nephrology, Hospital Universitari Arnau de Vilanova, Lleida, SpainDepartment of Nephrology, Hospital Universitari Arnau de Vilanova, Lleida, SpainDepartment of Nephrology, Hospital Universitari Arnau de Vilanova, Lleida, SpainVascular and Renal Translational Research Group, Institut de Recerca Biomedica de Lleida (IRBLleida), Lleida, SpainDepartment of Endocrinology and Nutrition, CIBER of Diabetes and Associated Metabolic Diseases, Hospital Universitari Germans Trias i Pujol, Badalona, SpainVascular and Renal Translational Research Group, Institut de Recerca Biomedica de Lleida (IRBLleida), Lleida, SpainVascular and Renal Translational Research Group, Institut de Recerca Biomedica de Lleida (IRBLleida), Lleida, SpainVascular and Renal Translational Research Group, Institut de Recerca Biomedica de Lleida (IRBLleida), Lleida, SpainChronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefore, the aim of the study was to (1) evaluate if the carotid aVV in CKD patients increases in comparison to its physiological value of healthy patients; (2) explore which traditional or nontraditional risk factor including inflammation, bone and mineral metabolism, and anemia could be related to the aVV angiogenesis. CKD patients without previous cardiovascular events (44, stages 3-4; 37, stage 5D) and 65 healthy subjects were compared. The carotid aVV and the intima-media thickness (cIMT) were evaluated by ultrasound. CKD patients at stages 3-4 showed higher aVV of the right carotid artery even after adjusting for age. Importantly, a multiple linear regression model showed hemoglobin levels > 12.5 g/dL as the factor for an estimated higher aVV of the right carotid artery. In conclusion, the association of hemoglobin with higher aVV could suggest the role of high hemoglobin in the higher incidence of adverse cardiovascular outcomes in CKD patients.http://dx.doi.org/10.1155/2017/3795142 |
| spellingShingle | Maria Vittoria Arcidiacono Montserrat Martinez-Alonso Montserrat Belart Ana Vilar Marisa Martín Lourdes Craver Àngels Betriu Dídac Mauricio José Manuel Valdivielso Elvira Fernández Mercè Borràs High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease Mediators of Inflammation |
| title | High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease |
| title_full | High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease |
| title_fullStr | High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease |
| title_full_unstemmed | High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease |
| title_short | High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease |
| title_sort | high levels of hemoglobin promote carotid adventitial vasa vasorum neoangiogenesis in chronic kidney disease |
| url | http://dx.doi.org/10.1155/2017/3795142 |
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