Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis
Previous studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON). We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/2764538 |
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| author | Scott C. Kolbe Anneke van der Walt Helmut Butzkueven Alexander Klistorner Gary F. Egan Trevor J. Kilpatrick |
| author_facet | Scott C. Kolbe Anneke van der Walt Helmut Butzkueven Alexander Klistorner Gary F. Egan Trevor J. Kilpatrick |
| author_sort | Scott C. Kolbe |
| collection | DOAJ |
| description | Previous studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON). We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and primary visual cortex (V1). We measured DTI parameters [fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] from the optic radiations of 38 acute ON patients at presentation and 6 and 12 months after acute ON. In addition, we measured retinal nerve fibre layer thickness, visual evoked potential amplitude, optic radiation lesion load, and V1 thickness. At baseline, FA was reduced and RD and MD were increased compared to control. Over 12 months, FA reduced in patients at an average rate of −2.6% per annum (control = −0.51%; p=0.006). Change in FA, RD, and MD correlated with V1 thinning over 12 months (FA: R=0.450, p=0.006; RD: R=-0.428, p=0.009; MD: R=-0.365, p=0.029). In patients with no optic radiation lesions, AD significantly correlated with RNFL thinning at 12 months (R=0.489, p=0.039). In conclusion, DTI can detect optic radiation changes over 12 months following acute ON that correlate with optic nerve and V1 damage. |
| format | Article |
| id | doaj-art-1597f4410ea342f99de45a7e712b47e6 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Journal of Ophthalmology |
| spelling | doaj-art-1597f4410ea342f99de45a7e712b47e62025-02-03T05:54:20ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/27645382764538Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic NeuritisScott C. Kolbe0Anneke van der Walt1Helmut Butzkueven2Alexander Klistorner3Gary F. Egan4Trevor J. Kilpatrick5Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Neurology, Royal Melbourne Hospital, Parkville, VIC 3052, AustraliaSave Sight Institute, University of Sydney, Sydney, NSW 2000, AustraliaMonash Biomedical Imaging, Monash University, Clayton, VIC 3800, AustraliaDepartment of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, AustraliaPrevious studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON). We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and primary visual cortex (V1). We measured DTI parameters [fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] from the optic radiations of 38 acute ON patients at presentation and 6 and 12 months after acute ON. In addition, we measured retinal nerve fibre layer thickness, visual evoked potential amplitude, optic radiation lesion load, and V1 thickness. At baseline, FA was reduced and RD and MD were increased compared to control. Over 12 months, FA reduced in patients at an average rate of −2.6% per annum (control = −0.51%; p=0.006). Change in FA, RD, and MD correlated with V1 thinning over 12 months (FA: R=0.450, p=0.006; RD: R=-0.428, p=0.009; MD: R=-0.365, p=0.029). In patients with no optic radiation lesions, AD significantly correlated with RNFL thinning at 12 months (R=0.489, p=0.039). In conclusion, DTI can detect optic radiation changes over 12 months following acute ON that correlate with optic nerve and V1 damage.http://dx.doi.org/10.1155/2016/2764538 |
| spellingShingle | Scott C. Kolbe Anneke van der Walt Helmut Butzkueven Alexander Klistorner Gary F. Egan Trevor J. Kilpatrick Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis Journal of Ophthalmology |
| title | Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis |
| title_full | Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis |
| title_fullStr | Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis |
| title_full_unstemmed | Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis |
| title_short | Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis |
| title_sort | serial diffusion tensor imaging of the optic radiations after acute optic neuritis |
| url | http://dx.doi.org/10.1155/2016/2764538 |
| work_keys_str_mv | AT scottckolbe serialdiffusiontensorimagingoftheopticradiationsafteracuteopticneuritis AT annekevanderwalt serialdiffusiontensorimagingoftheopticradiationsafteracuteopticneuritis AT helmutbutzkueven serialdiffusiontensorimagingoftheopticradiationsafteracuteopticneuritis AT alexanderklistorner serialdiffusiontensorimagingoftheopticradiationsafteracuteopticneuritis AT garyfegan serialdiffusiontensorimagingoftheopticradiationsafteracuteopticneuritis AT trevorjkilpatrick serialdiffusiontensorimagingoftheopticradiationsafteracuteopticneuritis |