Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study
Objective Leukaemia is one of the most common cancers and may be associated with exposure to environmental carcinogens, especially outdoor air pollutants. The objective of this study was to investigate the association of ambient air pollution and leukaemia in Tehran, Iran.Design In this retrospectiv...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e060562.full |
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| author | Narges Khanjani Nino Künzli Zahra Khorrami Mohsen Pourkhosravani Marzieh Eslahi Maysam Rezapour Mohammad Esmail Akbari Heresh Amini Seyed Mahmood Taghavi-Shahri Koorosh Etemad |
| author_facet | Narges Khanjani Nino Künzli Zahra Khorrami Mohsen Pourkhosravani Marzieh Eslahi Maysam Rezapour Mohammad Esmail Akbari Heresh Amini Seyed Mahmood Taghavi-Shahri Koorosh Etemad |
| author_sort | Narges Khanjani |
| collection | DOAJ |
| description | Objective Leukaemia is one of the most common cancers and may be associated with exposure to environmental carcinogens, especially outdoor air pollutants. The objective of this study was to investigate the association of ambient air pollution and leukaemia in Tehran, Iran.Design In this retrospective cohort study, data about the residential district of leukaemia cases diagnosed from 2010 to 2016 were inquired from the Ministry of Health cancer database. Data from a previous study were used to determine long-term average exposure to different air pollutants in 22 districts of Tehran. Latent profile analysis (LPA) was used to classify pollutants in two exposure profiles. The association between air pollutants and leukaemia incidence was analysed by negative binomial regression.Setting Twenty-two districts of Tehran megacity.Participants Patients with leukaemia.Outcome measures The outcome variables were incidence rate ratios (IRR) of acute myeloid and lymphoid leukaemia across the districts of Tehran.Results The districts with higher concentrations for all pollutants were near the city centre. The IRR was positive but non-significant for most of the air pollutants. However, annual mean NOx was directly and significantly associated with total leukaemia incidence in the fully adjusted model (IRR (95% CI): 1.03 (1.003 to 1.06) per 10 ppb increase). Based on LPA, districts with a higher multiple air-pollutants profile were also associated with higher leukaemia incidence (IRR (95% CI): 1.003 (0.99 to 1.007) per 1 ppb increase).Conclusions Our study shows that districts with higher air pollution (nitrogen oxides and multipollutants) have higher incidence rates of leukaemia in Tehran, Iran. This study warrants conducting further research with individual human data and better control of confounding. |
| format | Article |
| id | doaj-art-15933a3a03d242fc8a9643bd5030c152 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-15933a3a03d242fc8a9643bd5030c1522025-01-27T16:40:10ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-060562Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort studyNarges Khanjani0Nino Künzli1Zahra Khorrami2Mohsen Pourkhosravani3Marzieh Eslahi4Maysam Rezapour5Mohammad Esmail Akbari6Heresh Amini7Seyed Mahmood Taghavi-Shahri8Koorosh Etemad9Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, IranUniversity of Basel, Basel, SwitzerlandOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Geography and Urban Planning, Shahid Bahonar University of Kerman, Kerman, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Kerman University of Medical Sciences, Kerman, IranDepartment of Paramedicine, Amol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, IranCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Public Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Public Health, University of Copenhagen, Copenhagen, DenmarkCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranObjective Leukaemia is one of the most common cancers and may be associated with exposure to environmental carcinogens, especially outdoor air pollutants. The objective of this study was to investigate the association of ambient air pollution and leukaemia in Tehran, Iran.Design In this retrospective cohort study, data about the residential district of leukaemia cases diagnosed from 2010 to 2016 were inquired from the Ministry of Health cancer database. Data from a previous study were used to determine long-term average exposure to different air pollutants in 22 districts of Tehran. Latent profile analysis (LPA) was used to classify pollutants in two exposure profiles. The association between air pollutants and leukaemia incidence was analysed by negative binomial regression.Setting Twenty-two districts of Tehran megacity.Participants Patients with leukaemia.Outcome measures The outcome variables were incidence rate ratios (IRR) of acute myeloid and lymphoid leukaemia across the districts of Tehran.Results The districts with higher concentrations for all pollutants were near the city centre. The IRR was positive but non-significant for most of the air pollutants. However, annual mean NOx was directly and significantly associated with total leukaemia incidence in the fully adjusted model (IRR (95% CI): 1.03 (1.003 to 1.06) per 10 ppb increase). Based on LPA, districts with a higher multiple air-pollutants profile were also associated with higher leukaemia incidence (IRR (95% CI): 1.003 (0.99 to 1.007) per 1 ppb increase).Conclusions Our study shows that districts with higher air pollution (nitrogen oxides and multipollutants) have higher incidence rates of leukaemia in Tehran, Iran. This study warrants conducting further research with individual human data and better control of confounding.https://bmjopen.bmj.com/content/12/6/e060562.full |
| spellingShingle | Narges Khanjani Nino Künzli Zahra Khorrami Mohsen Pourkhosravani Marzieh Eslahi Maysam Rezapour Mohammad Esmail Akbari Heresh Amini Seyed Mahmood Taghavi-Shahri Koorosh Etemad Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study BMJ Open |
| title | Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study |
| title_full | Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study |
| title_fullStr | Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study |
| title_full_unstemmed | Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study |
| title_short | Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study |
| title_sort | multiple air pollutants exposure and leukaemia incidence in tehran iran from 2010 to 2016 a retrospective cohort study |
| url | https://bmjopen.bmj.com/content/12/6/e060562.full |
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