Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018)
BackgroundEthylene oxide (EO) is widely used as a disinfectant and is also a common environmental pollutant. Exposure to EO has been associated with various systemic diseases, posing crucial health risks. However, EO is frequently employed as a sterilizing agent in orthopedics, while its association...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1511215/full |
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| author | Zhongshan Li Zhongshan Li Qi Qu Qi Qu Zhiyu Wang Zhiyu Wang Shuanglin Mou Rui Jiang Rui Jiang Wensheng Zhu Wensheng Zhu |
| author_facet | Zhongshan Li Zhongshan Li Qi Qu Qi Qu Zhiyu Wang Zhiyu Wang Shuanglin Mou Rui Jiang Rui Jiang Wensheng Zhu Wensheng Zhu |
| author_sort | Zhongshan Li |
| collection | DOAJ |
| description | BackgroundEthylene oxide (EO) is widely used as a disinfectant and is also a common environmental pollutant. Exposure to EO has been associated with various systemic diseases, posing crucial health risks. However, EO is frequently employed as a sterilizing agent in orthopedics, while its association with the risk of skeletal system diseases remains insufficiently evaluated. This study aims to investigate the association between EO exposure and the risk of Osteoarthritis (OA), a prevalent orthopedic condition.MethodsA total of 3,386 participants were selected from the National Health and Nutrition Examination Survey (NHANES) 2013–2014 and 2017–2018 cycles, including 952 individuals with OA. Box plots assessed EO concentration differences between OA and non-OA groups. Weighted logistic regression models and restricted cubic spline (RCS) models were used to evaluate the relationship between EO exposure and OA risk. Subgroup analysis and interaction test explored variations in the association across different characteristics.ResultsNo significant difference in EO concentrations was found between OA and non-OA groups. In multivariate logistic regression, high EO level exposure was significantly associated with increased OA risk. Additionally, a nonlinear U-shaped and J-shaped association was observed in the unadjusted and adjusted RCS models, respectively. Subgroup analysis revealed that the association between EO exposure and OA risk was more pronounced in the 20–40 and 40–65 age groups, never smokers (Not at all), and those with low calcium levels (< 8.5 mg/dL) or low vitamin D levels (< 75 nmol/L).ConclusionsEO exposure is associated with OA risk, exhibiting a J-shaped relationship, with this association being particularly pronounced in individuals under 65 years old or those with low calcium or vitamin D levels. Further prospective studies are needed to examine the association between EO exposure and OA risk. |
| format | Article |
| id | doaj-art-158ee57053d14fa298148d8f1fab335a |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-158ee57053d14fa298148d8f1fab335a2025-01-30T11:25:12ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011310.3389/fpubh.2025.15112151511215Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018)Zhongshan Li0Zhongshan Li1Qi Qu2Qi Qu3Zhiyu Wang4Zhiyu Wang5Shuanglin Mou6Rui Jiang7Rui Jiang8Wensheng Zhu9Wensheng Zhu10College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaMedical School, Hubei Minzu University, Enshi, ChinaMedical School, Hubei Minzu University, Enshi, ChinaDepartment of Osteology, Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine, Huanggang, ChinaMedical School, Hubei Minzu University, Enshi, ChinaDepartment of Osteology, Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine, Huanggang, ChinaDepartment of Osteology, Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine, Huanggang, ChinaCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaDepartment of Osteology, Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine, Huanggang, ChinaCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaDepartment of Osteology, Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine, Huanggang, ChinaBackgroundEthylene oxide (EO) is widely used as a disinfectant and is also a common environmental pollutant. Exposure to EO has been associated with various systemic diseases, posing crucial health risks. However, EO is frequently employed as a sterilizing agent in orthopedics, while its association with the risk of skeletal system diseases remains insufficiently evaluated. This study aims to investigate the association between EO exposure and the risk of Osteoarthritis (OA), a prevalent orthopedic condition.MethodsA total of 3,386 participants were selected from the National Health and Nutrition Examination Survey (NHANES) 2013–2014 and 2017–2018 cycles, including 952 individuals with OA. Box plots assessed EO concentration differences between OA and non-OA groups. Weighted logistic regression models and restricted cubic spline (RCS) models were used to evaluate the relationship between EO exposure and OA risk. Subgroup analysis and interaction test explored variations in the association across different characteristics.ResultsNo significant difference in EO concentrations was found between OA and non-OA groups. In multivariate logistic regression, high EO level exposure was significantly associated with increased OA risk. Additionally, a nonlinear U-shaped and J-shaped association was observed in the unadjusted and adjusted RCS models, respectively. Subgroup analysis revealed that the association between EO exposure and OA risk was more pronounced in the 20–40 and 40–65 age groups, never smokers (Not at all), and those with low calcium levels (< 8.5 mg/dL) or low vitamin D levels (< 75 nmol/L).ConclusionsEO exposure is associated with OA risk, exhibiting a J-shaped relationship, with this association being particularly pronounced in individuals under 65 years old or those with low calcium or vitamin D levels. Further prospective studies are needed to examine the association between EO exposure and OA risk.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1511215/fullosteoarthritisethylene oxideepidemiologyNHANEScross-sectional study |
| spellingShingle | Zhongshan Li Zhongshan Li Qi Qu Qi Qu Zhiyu Wang Zhiyu Wang Shuanglin Mou Rui Jiang Rui Jiang Wensheng Zhu Wensheng Zhu Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) Frontiers in Public Health osteoarthritis ethylene oxide epidemiology NHANES cross-sectional study |
| title | Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) |
| title_full | Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) |
| title_fullStr | Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) |
| title_full_unstemmed | Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) |
| title_short | Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) |
| title_sort | association between ethylene oxide exposure and osteoarthritis risk an analysis of nhanes data 2013 2014 and 2017 2018 |
| topic | osteoarthritis ethylene oxide epidemiology NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1511215/full |
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