Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology
Herpes simplex virus (HSV) pneumonia caused by aspiration from the oropharyngeal exudates is described. An 89-year-old Japanese male in a poor performance state complained of appetite loss followed by difficulty in swallowing, and bilateral pulmonary infiltrates with interstitial reactions were radi...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/7623576 |
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| author | Kentaro Odani Mitsuhiro Tachibana Rintaro Tamashima Yutaka Tsutsumi |
| author_facet | Kentaro Odani Mitsuhiro Tachibana Rintaro Tamashima Yutaka Tsutsumi |
| author_sort | Kentaro Odani |
| collection | DOAJ |
| description | Herpes simplex virus (HSV) pneumonia caused by aspiration from the oropharyngeal exudates is described. An 89-year-old Japanese male in a poor performance state complained of appetite loss followed by difficulty in swallowing, and bilateral pulmonary infiltrates with interstitial reactions were radiologically pointed out. Antibiotics administration was ineffective, and he died on the 6th day of hospitalization. At autopsy, HSV-induced multiple mucosal erosions were observed on the tongue, pharynx, epiglottis, and trachea. In bilateral lower lobes of the lung, HSV infected bronchiolar and type-II alveolar cells in association with acute interstitial reactions. The infected cells with intranuclear inclusion bodies were immunoreactive with HSV antiserum. HSV-1 infection was confirmed by immunostaining with monospecific monoclonal antibodies and by type-specific real-time polymerase chain reaction. It is very likely that HSV pneumonia was provoked by aspiration of infected exudates from the upper airway (namely, sequential infection from the tongue, epiglottis, and trachea to lung). Oropharyngeal herpes might cause anorexia and difficulty in swallowing, probably accelerating aspiration. The medical staff did not recognize the oropharyngeal lesions of this aged patient. We must realize again the importance of oral care for hospitalized patients to avoid aspiration pneumonia, including herpetic pneumonia. |
| format | Article |
| id | doaj-art-158c9bd649504e878b15e03007d3f8d3 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-158c9bd649504e878b15e03007d3f8d32025-02-03T06:01:53ZengWileyCase Reports in Pathology2090-67812090-679X2019-01-01201910.1155/2019/76235767623576Herpes Simplex Virus Pneumonia: Importance of Aspiration EtiologyKentaro Odani0Mitsuhiro Tachibana1Rintaro Tamashima2Yutaka Tsutsumi3Department of General Medicine (Junior Resident), Shimada Municipal Hospital, Shimada, Shizuoka, JapanDepartment of Diagnostic Pathology, Shimada Municipal Hospital, Shimada, Shizuoka, JapanDepartment of Cardiology, Shimada Municipal Hospital, Shimada, Shizuoka, JapanDepartment of Diagnostic Pathology, Shimada Municipal Hospital, Shimada, Shizuoka, JapanHerpes simplex virus (HSV) pneumonia caused by aspiration from the oropharyngeal exudates is described. An 89-year-old Japanese male in a poor performance state complained of appetite loss followed by difficulty in swallowing, and bilateral pulmonary infiltrates with interstitial reactions were radiologically pointed out. Antibiotics administration was ineffective, and he died on the 6th day of hospitalization. At autopsy, HSV-induced multiple mucosal erosions were observed on the tongue, pharynx, epiglottis, and trachea. In bilateral lower lobes of the lung, HSV infected bronchiolar and type-II alveolar cells in association with acute interstitial reactions. The infected cells with intranuclear inclusion bodies were immunoreactive with HSV antiserum. HSV-1 infection was confirmed by immunostaining with monospecific monoclonal antibodies and by type-specific real-time polymerase chain reaction. It is very likely that HSV pneumonia was provoked by aspiration of infected exudates from the upper airway (namely, sequential infection from the tongue, epiglottis, and trachea to lung). Oropharyngeal herpes might cause anorexia and difficulty in swallowing, probably accelerating aspiration. The medical staff did not recognize the oropharyngeal lesions of this aged patient. We must realize again the importance of oral care for hospitalized patients to avoid aspiration pneumonia, including herpetic pneumonia.http://dx.doi.org/10.1155/2019/7623576 |
| spellingShingle | Kentaro Odani Mitsuhiro Tachibana Rintaro Tamashima Yutaka Tsutsumi Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology Case Reports in Pathology |
| title | Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology |
| title_full | Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology |
| title_fullStr | Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology |
| title_full_unstemmed | Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology |
| title_short | Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology |
| title_sort | herpes simplex virus pneumonia importance of aspiration etiology |
| url | http://dx.doi.org/10.1155/2019/7623576 |
| work_keys_str_mv | AT kentaroodani herpessimplexviruspneumoniaimportanceofaspirationetiology AT mitsuhirotachibana herpessimplexviruspneumoniaimportanceofaspirationetiology AT rintarotamashima herpessimplexviruspneumoniaimportanceofaspirationetiology AT yutakatsutsumi herpessimplexviruspneumoniaimportanceofaspirationetiology |