Progesterone and Bone: Actions Promoting Bone Health in Women
Estradiol (E2) and progesterone (P4) collaborate within bone remodelling on resorption (E2) and formation (P4). We integrate evidence that P4 may prevent and, with antiresorptives, treat women's osteoporosis. P4 stimulates osteoblast differentiation in vitro. Menarche (E2) and onset of ovulatio...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2010/845180 |
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| author | Vanadin Seifert-Klauss Jerilynn C. Prior |
| author_facet | Vanadin Seifert-Klauss Jerilynn C. Prior |
| author_sort | Vanadin Seifert-Klauss |
| collection | DOAJ |
| description | Estradiol (E2) and progesterone (P4) collaborate within bone remodelling on resorption (E2) and formation (P4). We integrate evidence that P4 may prevent and, with antiresorptives, treat women's osteoporosis. P4 stimulates osteoblast differentiation in vitro. Menarche (E2) and onset of ovulation (P4) both contribute to peak BMD. Meta-analysis of 5 studies confirms that regularly cycling premenopausal women lose bone mineral density (BMD) related to subclinical ovulatory disturbances (SODs). Cyclic progestin prevents bone loss in healthy premenopausal women with amenorrhea or SOD. BMD loss is more rapid in perimenopause than postmenopause—decreased bone formation due to P4 deficiency contributes. In 4 placebo-controlled RCTs, BMD loss is not prevented by P4 in postmenopausal women with increased bone turnover. However, 5 studies of E2-MPA co-therapy show greater BMD increases versus E2 alone. P4 fracture data are lacking. P4 prevents bone loss in pre- and possibly perimenopausal women; progesterone co-therapy with antiresorptives may increase bone formation and BMD. |
| format | Article |
| id | doaj-art-1574cb5592fe4dc484e7894df03b05f2 |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-1574cb5592fe4dc484e7894df03b05f22025-02-03T05:52:41ZengWileyJournal of Osteoporosis2042-00642010-01-01201010.4061/2010/845180845180Progesterone and Bone: Actions Promoting Bone Health in WomenVanadin Seifert-Klauss0Jerilynn C. Prior1Frauenklinik der Technischen Universität München (TUM), Klinikum Rechts der Isar, Ismaninger Str., 22 81675 Muenchen, GermanyDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of British Columbia and Centre for Menstrual Cycle and Ovulation Research (CeMCOR), 2775 Laurel Street, Vancouver, BC, V5Z 1M9, CanadaEstradiol (E2) and progesterone (P4) collaborate within bone remodelling on resorption (E2) and formation (P4). We integrate evidence that P4 may prevent and, with antiresorptives, treat women's osteoporosis. P4 stimulates osteoblast differentiation in vitro. Menarche (E2) and onset of ovulation (P4) both contribute to peak BMD. Meta-analysis of 5 studies confirms that regularly cycling premenopausal women lose bone mineral density (BMD) related to subclinical ovulatory disturbances (SODs). Cyclic progestin prevents bone loss in healthy premenopausal women with amenorrhea or SOD. BMD loss is more rapid in perimenopause than postmenopause—decreased bone formation due to P4 deficiency contributes. In 4 placebo-controlled RCTs, BMD loss is not prevented by P4 in postmenopausal women with increased bone turnover. However, 5 studies of E2-MPA co-therapy show greater BMD increases versus E2 alone. P4 fracture data are lacking. P4 prevents bone loss in pre- and possibly perimenopausal women; progesterone co-therapy with antiresorptives may increase bone formation and BMD.http://dx.doi.org/10.4061/2010/845180 |
| spellingShingle | Vanadin Seifert-Klauss Jerilynn C. Prior Progesterone and Bone: Actions Promoting Bone Health in Women Journal of Osteoporosis |
| title | Progesterone and Bone: Actions Promoting Bone Health in Women |
| title_full | Progesterone and Bone: Actions Promoting Bone Health in Women |
| title_fullStr | Progesterone and Bone: Actions Promoting Bone Health in Women |
| title_full_unstemmed | Progesterone and Bone: Actions Promoting Bone Health in Women |
| title_short | Progesterone and Bone: Actions Promoting Bone Health in Women |
| title_sort | progesterone and bone actions promoting bone health in women |
| url | http://dx.doi.org/10.4061/2010/845180 |
| work_keys_str_mv | AT vanadinseifertklauss progesteroneandboneactionspromotingbonehealthinwomen AT jerilynncprior progesteroneandboneactionspromotingbonehealthinwomen |