Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy
The use of folic acid in the periconceptional period can prevent about 70% of neural tube defects (NTDs). In the remaining cases, no medical prevention is available, and those conditions should be defined as folate-resistant NTDs. Rodent models suggest that some folate-resistant NTDs can be prevente...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/5846286 |
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| author | Pietro Cavalli Elena Ronda |
| author_facet | Pietro Cavalli Elena Ronda |
| author_sort | Pietro Cavalli |
| collection | DOAJ |
| description | The use of folic acid in the periconceptional period can prevent about 70% of neural tube defects (NTDs). In the remaining cases, no medical prevention is available, and those conditions should be defined as folate-resistant NTDs. Rodent models suggest that some folate-resistant NTDs can be prevented by inositol (myoinositol and chiroinositol) supplementation prior to pregnancy. Should folic acid be combined with myoinositol periconceptional supplementation to reduce the overall risk of NTDs even in humans? Hereafter, we discuss the results from the PONTI study that strongly support both the effectiveness and safety of myoinositol periconceptional supplementation in preventing human NTDs. We further report on the largest case series of pregnancies treated with myoinositol and folic acid. At our institution, a sequential study during 12 years involved mothers at risk of fetal NTDs, and 29 babies from 27 pregnancies were born after periconceptional combined myoinositol and folic acid supplementation. No case of NTDs was observed, despite the high recurrence risk in the mothers. Taken together, those data suggest that periconceptional folic acid plus myoinositol can reduce both the occurrence and recurrence risks of NTDs in a greater number of cases than folic acid alone. |
| format | Article |
| id | doaj-art-156ff343baa846c395211aeb8ea03bb0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-156ff343baa846c395211aeb8ea03bb02025-02-03T06:14:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/58462865846286Myoinositol: The Bridge (PONTI) to Reach a Healthy PregnancyPietro Cavalli0Elena Ronda1Clinical Genetics, ASST Cremona, Via Concordia 1, 26100 Cremona, ItalyClinical Genetics, ASST Cremona, Via Concordia 1, 26100 Cremona, ItalyThe use of folic acid in the periconceptional period can prevent about 70% of neural tube defects (NTDs). In the remaining cases, no medical prevention is available, and those conditions should be defined as folate-resistant NTDs. Rodent models suggest that some folate-resistant NTDs can be prevented by inositol (myoinositol and chiroinositol) supplementation prior to pregnancy. Should folic acid be combined with myoinositol periconceptional supplementation to reduce the overall risk of NTDs even in humans? Hereafter, we discuss the results from the PONTI study that strongly support both the effectiveness and safety of myoinositol periconceptional supplementation in preventing human NTDs. We further report on the largest case series of pregnancies treated with myoinositol and folic acid. At our institution, a sequential study during 12 years involved mothers at risk of fetal NTDs, and 29 babies from 27 pregnancies were born after periconceptional combined myoinositol and folic acid supplementation. No case of NTDs was observed, despite the high recurrence risk in the mothers. Taken together, those data suggest that periconceptional folic acid plus myoinositol can reduce both the occurrence and recurrence risks of NTDs in a greater number of cases than folic acid alone.http://dx.doi.org/10.1155/2017/5846286 |
| spellingShingle | Pietro Cavalli Elena Ronda Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy International Journal of Endocrinology |
| title | Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy |
| title_full | Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy |
| title_fullStr | Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy |
| title_full_unstemmed | Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy |
| title_short | Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy |
| title_sort | myoinositol the bridge ponti to reach a healthy pregnancy |
| url | http://dx.doi.org/10.1155/2017/5846286 |
| work_keys_str_mv | AT pietrocavalli myoinositolthebridgepontitoreachahealthypregnancy AT elenaronda myoinositolthebridgepontitoreachahealthypregnancy |