Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials

Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials

Abstract Background Hypertriglyceridemia is an independent risk factor for cardiovascular diseases. In previous trials, apolipoprotein C-III (APOC3) inhibition through the antisense oligonucleotides volanesorsen, olezarsen, and plozasiran reduced triglyceride levels. However, the three medications’...

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Main Authors: Abdelrahman Mahmoud, Kerollos Abdelsayed, Ahmed Almahdy Mohamed, Qasi Najah, Anas Abdulkader, Karim Ali, Shehroze Tabassum, Mohamed Riad Abouzid, Basel Abdelazeem, James D. Mills
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Lipids in Health and Disease
Subjects:
Hyperlipidemia
APOC3
Triglycerides
APOC3 inhibitors
Systematic review
Network meta-analysis
Online Access:https://doi.org/10.1186/s12944-024-02389-2
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