Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mu...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/9170162 |
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| _version_ | 1832566735897624576 |
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| author | R. Alan Harris Rajesh Shah Emily B. Hollister Rune Rose Tronstad Nils Hovdenak Reka Szigeti James Versalovic Richard Kellermayer |
| author_facet | R. Alan Harris Rajesh Shah Emily B. Hollister Rune Rose Tronstad Nils Hovdenak Reka Szigeti James Versalovic Richard Kellermayer |
| author_sort | R. Alan Harris |
| collection | DOAJ |
| description | Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC. |
| format | Article |
| id | doaj-art-156079cb318849e59a568bf7a80a3d4b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-156079cb318849e59a568bf7a80a3d4b2025-02-03T01:03:15ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/91701629170162Colonic Mucosal Epigenome and Microbiome Development in Children and AdolescentsR. Alan Harris0Rajesh Shah1Emily B. Hollister2Rune Rose Tronstad3Nils Hovdenak4Reka Szigeti5James Versalovic6Richard Kellermayer7Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USASection of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Clinical Science, University of Bergen, 5020 Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, 5020 Bergen, NorwayDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USATexas Children’s Hospital, Houston, TX 77030, USAEpigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.http://dx.doi.org/10.1155/2016/9170162 |
| spellingShingle | R. Alan Harris Rajesh Shah Emily B. Hollister Rune Rose Tronstad Nils Hovdenak Reka Szigeti James Versalovic Richard Kellermayer Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents Journal of Immunology Research |
| title | Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents |
| title_full | Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents |
| title_fullStr | Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents |
| title_full_unstemmed | Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents |
| title_short | Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents |
| title_sort | colonic mucosal epigenome and microbiome development in children and adolescents |
| url | http://dx.doi.org/10.1155/2016/9170162 |
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