Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature
Cervical carcinoma is the most common malignancy of the female genital tract and represents the second most common malignancy in women worldwide. Histologically 85 to 90% of cervical cancers are squamous cell carcinoma. Osteoclastic giant cell rich squamous cell carcinoma is an unusual histological...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2014/415328 |
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| author | Lucía Alemán-Meza Gabriela Sofía Gómez-Macías Oralia Barboza-Quintana Raquel Garza-Guajardo Abelardo Loya-Solis |
| author_facet | Lucía Alemán-Meza Gabriela Sofía Gómez-Macías Oralia Barboza-Quintana Raquel Garza-Guajardo Abelardo Loya-Solis |
| author_sort | Lucía Alemán-Meza |
| collection | DOAJ |
| description | Cervical carcinoma is the most common malignancy of the female genital tract and represents the second most common malignancy in women worldwide. Histologically 85 to 90% of cervical cancers are squamous cell carcinoma. Osteoclastic giant cell rich squamous cell carcinoma is an unusual histological variant of which only 4 cases have been reported. We present the case of a 49-year-old woman with a 6-month history of irregular vaginal bleeding. Examination revealed a 2.7 cm polypoid mass in the anterior lip of the uterine cervix. The patient underwent hysterectomy with bilateral salpingo-oophorectomy. Microscopically the tumor was composed of infiltrative nests of poorly differentiated nonkeratinizing squamous cell carcinoma. Interspersed in between these tumor cells were numerous osteoclastic giant cells with abundant eosinophilic cytoplasm devoid of nuclear atypia, hyperchromatism, or mitotic activity. Immunohistochemistry was performed; CK and P63 were strongly positive in the squamous component and negative in the osteoclastic giant cells, while CD68 and Vimentin were strongly positive in the giant cell population and negative in the squamous component. The patient received chemo- and radiotherapy for recurrent disease identified 3 months later on a follow-up CT scan; 7 months after the surgical procedure the patient is clinically and radiologically disease-free. |
| format | Article |
| id | doaj-art-15576285c6e944d2b184628b4cda1926 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-15576285c6e944d2b184628b4cda19262025-02-03T06:11:36ZengWileyCase Reports in Pathology2090-67812090-679X2014-01-01201410.1155/2014/415328415328Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the LiteratureLucía Alemán-Meza0Gabriela Sofía Gómez-Macías1Oralia Barboza-Quintana2Raquel Garza-Guajardo3Abelardo Loya-Solis4Pathology Department, University Hospital “Dr. Jose E. Gonzalez” and the Autonomous University of Nuevo Leon Medical School, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and the Autonomous University of Nuevo Leon Medical School, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and the Autonomous University of Nuevo Leon Medical School, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and the Autonomous University of Nuevo Leon Medical School, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and the Autonomous University of Nuevo Leon Medical School, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoCervical carcinoma is the most common malignancy of the female genital tract and represents the second most common malignancy in women worldwide. Histologically 85 to 90% of cervical cancers are squamous cell carcinoma. Osteoclastic giant cell rich squamous cell carcinoma is an unusual histological variant of which only 4 cases have been reported. We present the case of a 49-year-old woman with a 6-month history of irregular vaginal bleeding. Examination revealed a 2.7 cm polypoid mass in the anterior lip of the uterine cervix. The patient underwent hysterectomy with bilateral salpingo-oophorectomy. Microscopically the tumor was composed of infiltrative nests of poorly differentiated nonkeratinizing squamous cell carcinoma. Interspersed in between these tumor cells were numerous osteoclastic giant cells with abundant eosinophilic cytoplasm devoid of nuclear atypia, hyperchromatism, or mitotic activity. Immunohistochemistry was performed; CK and P63 were strongly positive in the squamous component and negative in the osteoclastic giant cells, while CD68 and Vimentin were strongly positive in the giant cell population and negative in the squamous component. The patient received chemo- and radiotherapy for recurrent disease identified 3 months later on a follow-up CT scan; 7 months after the surgical procedure the patient is clinically and radiologically disease-free.http://dx.doi.org/10.1155/2014/415328 |
| spellingShingle | Lucía Alemán-Meza Gabriela Sofía Gómez-Macías Oralia Barboza-Quintana Raquel Garza-Guajardo Abelardo Loya-Solis Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature Case Reports in Pathology |
| title | Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature |
| title_full | Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature |
| title_fullStr | Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature |
| title_full_unstemmed | Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature |
| title_short | Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature |
| title_sort | osteoclastic giant cell rich squamous cell carcinoma of the uterine cervix a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2014/415328 |
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