miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5
miRNAs play a crucial part in multiple biological processes of cell proliferation, migration, apoptosis, and chemoresistance. In cancer, miRNAs can be divided into oncogenes or tumor suppressors on the basis of their functions in the carcinogenic process. The purpose of this study was to explore the...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/4649890 |
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| _version_ | 1832546248143405056 |
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| author | Jiahui Mao Lingxia Wang Junying Wu Yichun Wang Huiyan Wen Xueming Zhu Bo Wang Huan Yang |
| author_facet | Jiahui Mao Lingxia Wang Junying Wu Yichun Wang Huiyan Wen Xueming Zhu Bo Wang Huan Yang |
| author_sort | Jiahui Mao |
| collection | DOAJ |
| description | miRNAs play a crucial part in multiple biological processes of cell proliferation, migration, apoptosis, and chemoresistance. In cancer, miRNAs can be divided into oncogenes or tumor suppressors on the basis of their functions in the carcinogenic process. The purpose of this study was to explore the roles and clinical diagnostic value of miR-370-3p in breast cancer. Our results demonstrated that miR-370-3p significantly promoted proliferation, metastasis, and stemness of breast cancer in vitro and in vivo. In particular, clinical data revealed that high expression of serum miR-370-3p and exosomal miR-370-3p from breast cancer patients was remarkably correlated with lymphatic metastasis and tumor node metastasis (TNM) stages. Mechanistically, miR-370-3p inhibited FBLN5 expression and activated the NF-κB signaling pathway to promote breast cancer cell proliferation, migration, and stemness. FBLN5 expression was significantly decreased in breast cancer cells and tumor tissues of breast cancer patients. Our research identified that miR-370-3p promoted breast cancer progression by inhibiting FBLN5 expression and activating the NF-κB signaling pathway. Serum exosomal miR-370-3p would provide a potential biomarker for the diagnosis of breast cancer. |
| format | Article |
| id | doaj-art-1523cd3245514852bb495f93e239c7e3 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1523cd3245514852bb495f93e239c7e32025-02-03T07:23:30ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/46498904649890miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5Jiahui Mao0Lingxia Wang1Junying Wu2Yichun Wang3Huiyan Wen4Xueming Zhu5Bo Wang6Huan Yang7Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004 Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004 Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004 Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004 Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004 Jiangsu, ChinaDepartment of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004 Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004 Jiangsu, ChinamiRNAs play a crucial part in multiple biological processes of cell proliferation, migration, apoptosis, and chemoresistance. In cancer, miRNAs can be divided into oncogenes or tumor suppressors on the basis of their functions in the carcinogenic process. The purpose of this study was to explore the roles and clinical diagnostic value of miR-370-3p in breast cancer. Our results demonstrated that miR-370-3p significantly promoted proliferation, metastasis, and stemness of breast cancer in vitro and in vivo. In particular, clinical data revealed that high expression of serum miR-370-3p and exosomal miR-370-3p from breast cancer patients was remarkably correlated with lymphatic metastasis and tumor node metastasis (TNM) stages. Mechanistically, miR-370-3p inhibited FBLN5 expression and activated the NF-κB signaling pathway to promote breast cancer cell proliferation, migration, and stemness. FBLN5 expression was significantly decreased in breast cancer cells and tumor tissues of breast cancer patients. Our research identified that miR-370-3p promoted breast cancer progression by inhibiting FBLN5 expression and activating the NF-κB signaling pathway. Serum exosomal miR-370-3p would provide a potential biomarker for the diagnosis of breast cancer.http://dx.doi.org/10.1155/2021/4649890 |
| spellingShingle | Jiahui Mao Lingxia Wang Junying Wu Yichun Wang Huiyan Wen Xueming Zhu Bo Wang Huan Yang miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 Stem Cells International |
| title | miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 |
| title_full | miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 |
| title_fullStr | miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 |
| title_full_unstemmed | miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 |
| title_short | miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 |
| title_sort | mir 370 3p as a novel biomarker promotes breast cancer progression by targeting fbln5 |
| url | http://dx.doi.org/10.1155/2021/4649890 |
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