Preferential cleavage of the coronavirus defective viral genome by cellular endoribonuclease with characteristics of RNase L

Preferential cleavage of the coronavirus defective viral genome by cellular endoribonuclease with characteristics of RNase L

Abstract In testing whether coronavirus defective viral genome 12.7 (DVG12.7) with transcription regulating sequence (TRS) can synthesize subgenomic mRNA (sgmRNA) in coronavirus-infected cells, it was unexpectedly found by Northern blot assay that not only sgmRNA (designated sgmDVG 12.7) but also an...

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Bibliographic Details
Main Authors: Ching-Hung Lin, Hsuan-Yung Lin, Chun-Chun Yang, Hsuan-Wei Hsu, Feng-Cheng Hsieh, Cheng-Yao Yang, Hung-Yi Wu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Virology Journal
Subjects:
Coronavirus
Defective viral genome
RNA cleavage
Endoribonuclease
RNase L
Online Access:https://doi.org/10.1186/s12985-024-02549-x
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