Oligodendrocyte Injury in Multiple Sclerosis.
Introduction: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS), marked by inflammation, demyelination, and significant oligodendrocyte injury. This disease arises from a complex interplay of genetic predispositions and environmental triggers that drive im...
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Albanian Society for Trauma and Emergency Surgery
2025-01-01
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| Series: | Albanian Journal of Trauma and Emergency Surgery |
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| Online Access: | http://journal.astes.org.al/AJTES/index.php/AJTES/article/view/443 |
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| author | Mateo Përgjegji Klei Bame Ketrina Ceka Jera Cenalia Sibora Bërdica Teona Bushati |
| author_facet | Mateo Përgjegji Klei Bame Ketrina Ceka Jera Cenalia Sibora Bërdica Teona Bushati |
| author_sort | Mateo Përgjegji |
| collection | DOAJ |
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Introduction: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS), marked by inflammation, demyelination, and significant oligodendrocyte injury. This disease arises from a complex interplay of genetic predispositions and environmental triggers that drive immune-mediated damage to oligodendrocytes and myelin proteins.
This research paper explores the multifaceted aspects of oligodendrocyte injury in MS, ranging from underlying pathophysiological mechanisms to potential therapeutic interventions and translational implications for clinical practice.
Oligodendrocyte damage in MS occurs via multiple mechanisms, including metabolic stress, oxidative damage, and cytokine-induced apoptosis, mainly mediated by interferon-gamma (IFN-γ) signaling. This process exacerbates neuroinflammation and contributes to disease progression. Emerging therapeutic strategies, such as targeting metabolic pathways, reducing oxidative stress, and enhancing autophagy, have demonstrated potential in preclinical studies. Furthermore, stem cell therapies are being explored for their ability to regenerate oligodendrocytes and restore myelin integrity.
Conclusions: The intricate interplay among oligodendrocyte injury, demyelination, and neuroinflammation is central to multiple sclerosis (MS) pathogenesis. Oligodendrocytes safeguard myelin in the CNS, facing challenges from immune attacks to metabolic stress. Understanding oligodendrocyte dysfunction is vital for targeted therapies that suppress immune damage and promote remyelination and CNS repair. MS's etiology,
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| format | Article |
| id | doaj-art-15128fe533e84b2c980c4504df15bf97 |
| institution | Kabale University |
| issn | 2521-8778 2616-4922 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Albanian Society for Trauma and Emergency Surgery |
| record_format | Article |
| series | Albanian Journal of Trauma and Emergency Surgery |
| spelling | doaj-art-15128fe533e84b2c980c4504df15bf972025-01-19T14:24:38ZengAlbanian Society for Trauma and Emergency SurgeryAlbanian Journal of Trauma and Emergency Surgery2521-87782616-49222025-01-019110.32391/ajtes.v9i1.443Oligodendrocyte Injury in Multiple Sclerosis.Mateo Përgjegji0Klei Bame1Ketrina Ceka2Jera Cenalia 3Sibora Bërdica 4Teona Bushati5Faculty of Medicine, "Western Balkans University," Tirana, ALBANIAFaculty of Medicine, "Western Balkans University," Tirana, ALBANIAFaculty of Medicine, "Western Balkans University," Tirana, ALBANIAFaculty of Medicine, "Western Balkans University," Tirana, ALBANIAFaculty of Medicine, "Western Balkans University," Tirana, ALBANIA Department of Pathological Anatomy and Forensic Medicine, University of Medicine Tirana, ALBANIA Introduction: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS), marked by inflammation, demyelination, and significant oligodendrocyte injury. This disease arises from a complex interplay of genetic predispositions and environmental triggers that drive immune-mediated damage to oligodendrocytes and myelin proteins. This research paper explores the multifaceted aspects of oligodendrocyte injury in MS, ranging from underlying pathophysiological mechanisms to potential therapeutic interventions and translational implications for clinical practice. Oligodendrocyte damage in MS occurs via multiple mechanisms, including metabolic stress, oxidative damage, and cytokine-induced apoptosis, mainly mediated by interferon-gamma (IFN-γ) signaling. This process exacerbates neuroinflammation and contributes to disease progression. Emerging therapeutic strategies, such as targeting metabolic pathways, reducing oxidative stress, and enhancing autophagy, have demonstrated potential in preclinical studies. Furthermore, stem cell therapies are being explored for their ability to regenerate oligodendrocytes and restore myelin integrity. Conclusions: The intricate interplay among oligodendrocyte injury, demyelination, and neuroinflammation is central to multiple sclerosis (MS) pathogenesis. Oligodendrocytes safeguard myelin in the CNS, facing challenges from immune attacks to metabolic stress. Understanding oligodendrocyte dysfunction is vital for targeted therapies that suppress immune damage and promote remyelination and CNS repair. MS's etiology, http://journal.astes.org.al/AJTES/index.php/AJTES/article/view/443Multiple sclerosisoligodendrocytesneuroinflammationneurodegenerationdemyelinationimmune system |
| spellingShingle | Mateo Përgjegji Klei Bame Ketrina Ceka Jera Cenalia Sibora Bërdica Teona Bushati Oligodendrocyte Injury in Multiple Sclerosis. Albanian Journal of Trauma and Emergency Surgery Multiple sclerosis oligodendrocytes neuroinflammation neurodegeneration demyelination immune system |
| title | Oligodendrocyte Injury in Multiple Sclerosis. |
| title_full | Oligodendrocyte Injury in Multiple Sclerosis. |
| title_fullStr | Oligodendrocyte Injury in Multiple Sclerosis. |
| title_full_unstemmed | Oligodendrocyte Injury in Multiple Sclerosis. |
| title_short | Oligodendrocyte Injury in Multiple Sclerosis. |
| title_sort | oligodendrocyte injury in multiple sclerosis |
| topic | Multiple sclerosis oligodendrocytes neuroinflammation neurodegeneration demyelination immune system |
| url | http://journal.astes.org.al/AJTES/index.php/AJTES/article/view/443 |
| work_keys_str_mv | AT mateopergjegji oligodendrocyteinjuryinmultiplesclerosis AT kleibame oligodendrocyteinjuryinmultiplesclerosis AT ketrinaceka oligodendrocyteinjuryinmultiplesclerosis AT jeracenalia oligodendrocyteinjuryinmultiplesclerosis AT siboraberdica oligodendrocyteinjuryinmultiplesclerosis AT teonabushati oligodendrocyteinjuryinmultiplesclerosis |