A Case of TAFRO Syndrome Developed after COVID-19 Vaccination
TAFRO syndrome is a systemic inflammatory disorder, which is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. It often presents with progressive clinical symptoms and can be fatal. COVID-19 vaccination is important to reduce the number...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2023/7292895 |
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| author | Hitomi Hirose Hitoshi Suzuki Yukako Umezawa Masako Iwasaki Hiromitsu Fukuda Hisatsugu Takahara Shigeki Tomita Yusuke Suzuki |
| author_facet | Hitomi Hirose Hitoshi Suzuki Yukako Umezawa Masako Iwasaki Hiromitsu Fukuda Hisatsugu Takahara Shigeki Tomita Yusuke Suzuki |
| author_sort | Hitomi Hirose |
| collection | DOAJ |
| description | TAFRO syndrome is a systemic inflammatory disorder, which is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. It often presents with progressive clinical symptoms and can be fatal. COVID-19 vaccination is important to reduce the number of COVID-19-infected populations and lower the risk of becoming severe. However, serious adverse events have been reported. TAFRO syndrome that progresses after the COVID-19 mRNA vaccination has not yet been reported. A 45-year-old man developed fever, gross hematuria, renal dysfunction, pleural effusions, and ascites immediately after vaccination. This case fulfilled three major categories (thrombocytopenia, anasarca, and systemic inflammation) and two minor categories (renal insufficiency and myelofibrosis) and was diagnosed with TAFRO syndrome. High-dose steroid treatment was initiated, followed by prednisolone administration. After treatment, renal dysfunction and fluid retention were resolved. Universal vaccination against COVID-19 is important for lowering the risk of spreading COVID-19 infection. Several complications, such as renal, hematological, and heart diseases, have been reported; however, its pathogenesis is unclear. The possibility of various complications after the COVID-19 vaccination, including TAFRO syndrome, should be considered. |
| format | Article |
| id | doaj-art-15113e4f172948509340338505e67ee7 |
| institution | Kabale University |
| issn | 2090-665X |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-15113e4f172948509340338505e67ee72025-02-03T06:42:47ZengWileyCase Reports in Nephrology2090-665X2023-01-01202310.1155/2023/7292895A Case of TAFRO Syndrome Developed after COVID-19 VaccinationHitomi Hirose0Hitoshi Suzuki1Yukako Umezawa2Masako Iwasaki3Hiromitsu Fukuda4Hisatsugu Takahara5Shigeki Tomita6Yusuke Suzuki7Department of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of PathologyDepartment of NephrologyTAFRO syndrome is a systemic inflammatory disorder, which is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. It often presents with progressive clinical symptoms and can be fatal. COVID-19 vaccination is important to reduce the number of COVID-19-infected populations and lower the risk of becoming severe. However, serious adverse events have been reported. TAFRO syndrome that progresses after the COVID-19 mRNA vaccination has not yet been reported. A 45-year-old man developed fever, gross hematuria, renal dysfunction, pleural effusions, and ascites immediately after vaccination. This case fulfilled three major categories (thrombocytopenia, anasarca, and systemic inflammation) and two minor categories (renal insufficiency and myelofibrosis) and was diagnosed with TAFRO syndrome. High-dose steroid treatment was initiated, followed by prednisolone administration. After treatment, renal dysfunction and fluid retention were resolved. Universal vaccination against COVID-19 is important for lowering the risk of spreading COVID-19 infection. Several complications, such as renal, hematological, and heart diseases, have been reported; however, its pathogenesis is unclear. The possibility of various complications after the COVID-19 vaccination, including TAFRO syndrome, should be considered.http://dx.doi.org/10.1155/2023/7292895 |
| spellingShingle | Hitomi Hirose Hitoshi Suzuki Yukako Umezawa Masako Iwasaki Hiromitsu Fukuda Hisatsugu Takahara Shigeki Tomita Yusuke Suzuki A Case of TAFRO Syndrome Developed after COVID-19 Vaccination Case Reports in Nephrology |
| title | A Case of TAFRO Syndrome Developed after COVID-19 Vaccination |
| title_full | A Case of TAFRO Syndrome Developed after COVID-19 Vaccination |
| title_fullStr | A Case of TAFRO Syndrome Developed after COVID-19 Vaccination |
| title_full_unstemmed | A Case of TAFRO Syndrome Developed after COVID-19 Vaccination |
| title_short | A Case of TAFRO Syndrome Developed after COVID-19 Vaccination |
| title_sort | case of tafro syndrome developed after covid 19 vaccination |
| url | http://dx.doi.org/10.1155/2023/7292895 |
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