Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer
Objective: Angiotropism/perivascular invasion (PVI) is an emerging topic in various types of cancer, with studies primarily focusing on melanoma. However, limited data are available on the significance of PVI in breast cancer. This study aimed to assess the prognostic significance of PVI in breast c...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-12-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-66169 |
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| author | Begüm Çalım GÜRBÜZ Tuçe Söylemez AKKURT Handan EREN Hazal İzol ÖZMEN Ebru ŞEN Burçin PEHLİVANOĞLU |
| author_facet | Begüm Çalım GÜRBÜZ Tuçe Söylemez AKKURT Handan EREN Hazal İzol ÖZMEN Ebru ŞEN Burçin PEHLİVANOĞLU |
| author_sort | Begüm Çalım GÜRBÜZ |
| collection | DOAJ |
| description | Objective: Angiotropism/perivascular invasion (PVI) is an emerging topic in various types of cancer, with studies primarily focusing on melanoma. However, limited data are available on the significance of PVI in breast cancer. This study aimed to assess the prognostic significance of PVI in breast cancer and its correlation with traditional clinicopathological prognostic parameters.
Methods: A total of 150 patients with breast cancer diagnosed between July 2020 and January 2022 were included. Clinicopathological data were retrieved from the hospital records. The presence of PVI was evaluated on hematoxylin&eosin stained slides, and the association between PVI and clinicopathological parameters was statistically analyzed. A p-value of <0.05 was regarded as statistically significant.
Results: All patients were female. The mean age was 54.0+-13.6 years (range 26-97 years). PVI was significantly more common in patients with ≥2.5 cm tumors and the absence of PVI showed a significant correlation with a lower histologic grade (p=0.004 and p=0.040, respectively). Lymphovascular invasion (LVI) and perineural invasion (PNI) were also significantly more frequent in tumors with PVI (p=0.001 and 0.02, respectively). There was a statistically significant association between the absence of both PVI and extranodal extension (ENE) (p=0.035).
Conclusions: The specific role of PVI in different types of cancer has not yet been clarified. Our findings showed that PVI was significantly associated with tumor size, histological grade, LVI, PNI, and ENE, all of which are well-known negative prognostic factors in breast cancer. The presence of PVI is a promising topic in breast cancer research, and the PVI status in pathology reports may help oncologists perform better risk assessments for patients with breast carcinoma. |
| format | Article |
| id | doaj-art-150eb518e73946e19f025587d97bf329 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-150eb518e73946e19f025587d97bf3292025-01-29T10:02:16ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062024-12-0139430230810.4274/MMJ.galenos.2024.66169MEDJ-66169Perivascular Invasion: A Promising Prognostic Parameter for Breast CancerBegüm Çalım GÜRBÜZ0Tuçe Söylemez AKKURT1Handan EREN2Hazal İzol ÖZMEN3Ebru ŞEN4Burçin PEHLİVANOĞLU5Başakşehir Çam and Sakura City Hospital, Clinic of Medical Pathology, İstanbul, TürkiyeBaşakşehir Çam and Sakura City Hospital, Clinic of Medical Pathology, İstanbul, TürkiyeBaşakşehir Çam and Sakura City Hospital, Clinic of Medical Pathology, İstanbul, TürkiyeBaşakşehir Çam and Sakura City Hospital, Clinic of Medical Pathology, İstanbul, TürkiyeBaşakşehir Çam and Sakura City Hospital, Clinic of General Surgery, İstanbul, TürkiyeDokuz Eylül University Faculty of Medicine, Departmet of Medical Pathology, İzmir, TürkiyeObjective: Angiotropism/perivascular invasion (PVI) is an emerging topic in various types of cancer, with studies primarily focusing on melanoma. However, limited data are available on the significance of PVI in breast cancer. This study aimed to assess the prognostic significance of PVI in breast cancer and its correlation with traditional clinicopathological prognostic parameters. Methods: A total of 150 patients with breast cancer diagnosed between July 2020 and January 2022 were included. Clinicopathological data were retrieved from the hospital records. The presence of PVI was evaluated on hematoxylin&eosin stained slides, and the association between PVI and clinicopathological parameters was statistically analyzed. A p-value of <0.05 was regarded as statistically significant. Results: All patients were female. The mean age was 54.0+-13.6 years (range 26-97 years). PVI was significantly more common in patients with ≥2.5 cm tumors and the absence of PVI showed a significant correlation with a lower histologic grade (p=0.004 and p=0.040, respectively). Lymphovascular invasion (LVI) and perineural invasion (PNI) were also significantly more frequent in tumors with PVI (p=0.001 and 0.02, respectively). There was a statistically significant association between the absence of both PVI and extranodal extension (ENE) (p=0.035). Conclusions: The specific role of PVI in different types of cancer has not yet been clarified. Our findings showed that PVI was significantly associated with tumor size, histological grade, LVI, PNI, and ENE, all of which are well-known negative prognostic factors in breast cancer. The presence of PVI is a promising topic in breast cancer research, and the PVI status in pathology reports may help oncologists perform better risk assessments for patients with breast carcinoma.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-66169breastcancerperivascular invasionangiotropismprognosis |
| spellingShingle | Begüm Çalım GÜRBÜZ Tuçe Söylemez AKKURT Handan EREN Hazal İzol ÖZMEN Ebru ŞEN Burçin PEHLİVANOĞLU Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer Medeniyet Medical Journal breast cancer perivascular invasion angiotropism prognosis |
| title | Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer |
| title_full | Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer |
| title_fullStr | Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer |
| title_full_unstemmed | Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer |
| title_short | Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer |
| title_sort | perivascular invasion a promising prognostic parameter for breast cancer |
| topic | breast cancer perivascular invasion angiotropism prognosis |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-66169 |
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