When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune Myopathy
Statins are notorious for causing myalgia and sometimes mild elevation of CPK (creatine phosphokinase). Herein, we present a case of necrotizing autoimmune myopathy induced by statins. The patient was on therapy with atorvastatin for about six years before she started developing myalgia and mild ele...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2018/1215653 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563475220529152 |
|---|---|
| author | Elena Obreja Pamela Sequeira Diana Girnita |
| author_facet | Elena Obreja Pamela Sequeira Diana Girnita |
| author_sort | Elena Obreja |
| collection | DOAJ |
| description | Statins are notorious for causing myalgia and sometimes mild elevation of CPK (creatine phosphokinase). Herein, we present a case of necrotizing autoimmune myopathy induced by statins. The patient was on therapy with atorvastatin for about six years before she started developing myalgia and mild elevation in CPK that resolved after discontinuation of therapy. Since her cardiovascular risk was high and she had hypercholesterolemia, three months after CPK levels normalization, she was re-challenged with pravastatin. Few months later, she again presented severe myalgia, weakness, and elevated CPK levels. Hence, medication was discontinued, and she undergone an extensive workup for possible causes of inflammatory myopathies that revealed necrotizing autoimmune myopathy. Our case report offers an excellent source of “identification patterns” of muscular autoimmune disease which can be easily mistaken as common side effect of a drug. |
| format | Article |
| id | doaj-art-14f4e48550e84948bf82ed2012132947 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-14f4e48550e84948bf82ed20121329472025-02-03T01:20:04ZengWileyCase Reports in Rheumatology2090-68892090-68972018-01-01201810.1155/2018/12156531215653When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune MyopathyElena Obreja0Pamela Sequeira1Diana Girnita2Internal Medicine Resident, Weiss Memorial Hospital, Chicago, IL, USADepartment of Pathology, Trihealth Hospitals, Cincinnati, OH, USADepartment of Rheumatology, Trihealth Physician Partners, Cincinnati, OH, USAStatins are notorious for causing myalgia and sometimes mild elevation of CPK (creatine phosphokinase). Herein, we present a case of necrotizing autoimmune myopathy induced by statins. The patient was on therapy with atorvastatin for about six years before she started developing myalgia and mild elevation in CPK that resolved after discontinuation of therapy. Since her cardiovascular risk was high and she had hypercholesterolemia, three months after CPK levels normalization, she was re-challenged with pravastatin. Few months later, she again presented severe myalgia, weakness, and elevated CPK levels. Hence, medication was discontinued, and she undergone an extensive workup for possible causes of inflammatory myopathies that revealed necrotizing autoimmune myopathy. Our case report offers an excellent source of “identification patterns” of muscular autoimmune disease which can be easily mistaken as common side effect of a drug.http://dx.doi.org/10.1155/2018/1215653 |
| spellingShingle | Elena Obreja Pamela Sequeira Diana Girnita When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune Myopathy Case Reports in Rheumatology |
| title | When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune Myopathy |
| title_full | When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune Myopathy |
| title_fullStr | When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune Myopathy |
| title_full_unstemmed | When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune Myopathy |
| title_short | When Should a Patient with Statin-Induced Myopathy Be Re-challenged? A Case of Necrotizing Autoimmune Myopathy |
| title_sort | when should a patient with statin induced myopathy be re challenged a case of necrotizing autoimmune myopathy |
| url | http://dx.doi.org/10.1155/2018/1215653 |
| work_keys_str_mv | AT elenaobreja whenshouldapatientwithstatininducedmyopathyberechallengedacaseofnecrotizingautoimmunemyopathy AT pamelasequeira whenshouldapatientwithstatininducedmyopathyberechallengedacaseofnecrotizingautoimmunemyopathy AT dianagirnita whenshouldapatientwithstatininducedmyopathyberechallengedacaseofnecrotizingautoimmunemyopathy |