Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
It is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we m...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/3898924 |
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| author | Hyun Ho Jung Jaewoo Shin Jinhyung Kim Seung-Hee Ahn Sung Eun Lee Chin Su Koh Jae Sung Cho Chanho Kong Hyung-Cheul Shin Sung June Kim Jin Woo Chang |
| author_facet | Hyun Ho Jung Jaewoo Shin Jinhyung Kim Seung-Hee Ahn Sung Eun Lee Chin Su Koh Jae Sung Cho Chanho Kong Hyung-Cheul Shin Sung June Kim Jin Woo Chang |
| author_sort | Hyun Ho Jung |
| collection | DOAJ |
| description | It is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n=7) and Group B (NP + RAIC lesion + MCS; n=7). Also, we simultaneously recorded neuronal activity (NP; n=9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. The pain threshold and tolerance latency increased in Group A with “MCS on” and in Group B with or without “MCS on.” Moreover, its increase in Group B with “MCS on” was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation. Compared with the “MCS off” condition, the “MCS on” induced significant threshold changes in an electrophysiological study. Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS. |
| format | Article |
| id | doaj-art-14e3097755e14b75bb3948a6c3aee6e4 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-14e3097755e14b75bb3948a6c3aee6e42025-02-03T01:11:47ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/38989243898924Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain ModelHyun Ho Jung0Jaewoo Shin1Jinhyung Kim2Seung-Hee Ahn3Sung Eun Lee4Chin Su Koh5Jae Sung Cho6Chanho Kong7Hyung-Cheul Shin8Sung June Kim9Jin Woo Chang10Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Electrical and Computer Engineering, College of Engineering, Seoul National University, Seoul, Republic of KoreaDepartment of Electrical and Computer Engineering, College of Engineering, Seoul National University, Seoul, Republic of KoreaDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Physiology, Hallym University College of Medicine, Chuncheon, Republic of KoreaDepartment of Electrical and Computer Engineering, College of Engineering, Seoul National University, Seoul, Republic of KoreaDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaIt is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n=7) and Group B (NP + RAIC lesion + MCS; n=7). Also, we simultaneously recorded neuronal activity (NP; n=9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. The pain threshold and tolerance latency increased in Group A with “MCS on” and in Group B with or without “MCS on.” Moreover, its increase in Group B with “MCS on” was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation. Compared with the “MCS off” condition, the “MCS on” induced significant threshold changes in an electrophysiological study. Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS.http://dx.doi.org/10.1155/2016/3898924 |
| spellingShingle | Hyun Ho Jung Jaewoo Shin Jinhyung Kim Seung-Hee Ahn Sung Eun Lee Chin Su Koh Jae Sung Cho Chanho Kong Hyung-Cheul Shin Sung June Kim Jin Woo Chang Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model Neural Plasticity |
| title | Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model |
| title_full | Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model |
| title_fullStr | Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model |
| title_full_unstemmed | Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model |
| title_short | Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model |
| title_sort | rostral agranular insular cortex lesion with motor cortex stimulation enhances pain modulation effect on neuropathic pain model |
| url | http://dx.doi.org/10.1155/2016/3898924 |
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