Effect of prednisolone acetate eye drops on blood glucose profile in Indian population
Background: One of the common indications of topical steroids is to control postoperative inflammation. This study aims to evaluate changes in blood glucose concentrations in diabetic and nondiabetic patients treated with a postoperative regimen of 1% topical prednisolone acetate after cataract surg...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Journal of Clinical Ophthalmology and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_95_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087201462091776 |
|---|---|
| author | Archana Bhat Prajakta Paritekar Y. Umesh |
| author_facet | Archana Bhat Prajakta Paritekar Y. Umesh |
| author_sort | Archana Bhat |
| collection | DOAJ |
| description | Background:
One of the common indications of topical steroids is to control postoperative inflammation. This study aims to evaluate changes in blood glucose concentrations in diabetic and nondiabetic patients treated with a postoperative regimen of 1% topical prednisolone acetate after cataract surgery.
Materials and Methods:
Prospective, observational cohort study conducted in a tertiary eye care hospital in South India from August 2022 to May 2023. Nondiabetics (Group A) and diabetics with good glycemic control, i.e., glycated hemoglobin (HbA1c) <7% (Group B) undergoing routine uneventful cataract surgery by a single surgeon were included in the study. All patients were prescribed the same regimen of topical corticosteroids after cataract surgery for 2 weeks, i.e., topical prednisolone acetate 1%, 1 drop six times a day for 1 week followed by three times a day for 1 week. All patients underwent capillary fasting blood sugar (FBS) test at the following time points: before the start of surgery, 1-week postoperative, 1-month postoperative, and HbA1c at 3 months postoperative.
Results:
Forty nondiabetic patients (Group A) and 40 well-controlled diabetic patients (Group B) were included in the study. Group A showed a statistically significant increase when 1-week preoperative FBS level (105.9 ± 13.3) was compared with 1-week postoperative (114.42 ± 15.6) which returned to the pretreatment level (102.92 ± 8.9) on 1-month follow-up. In Group B, 1-week preoperative (126.05 ± 31.2) and 1-week postoperative FBS levels (126.37 ± 19.5) were comparable.
Conclusion:
Topical prednisolone acetate can be safely used as a short-term routine postcataract surgery regimen in nondiabetics and diabetics with good glycemic control, without a significant increase in blood sugar levels. |
| format | Article |
| id | doaj-art-14e28bbc587d4bb9ae0196f2aefcde73 |
| institution | Kabale University |
| issn | 2320-3897 2320-3900 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj-art-14e28bbc587d4bb9ae0196f2aefcde732025-02-06T06:38:52ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972320-39002025-01-01131576010.4103/jcor.jcor_95_24Effect of prednisolone acetate eye drops on blood glucose profile in Indian populationArchana BhatPrajakta ParitekarY. UmeshBackground: One of the common indications of topical steroids is to control postoperative inflammation. This study aims to evaluate changes in blood glucose concentrations in diabetic and nondiabetic patients treated with a postoperative regimen of 1% topical prednisolone acetate after cataract surgery. Materials and Methods: Prospective, observational cohort study conducted in a tertiary eye care hospital in South India from August 2022 to May 2023. Nondiabetics (Group A) and diabetics with good glycemic control, i.e., glycated hemoglobin (HbA1c) <7% (Group B) undergoing routine uneventful cataract surgery by a single surgeon were included in the study. All patients were prescribed the same regimen of topical corticosteroids after cataract surgery for 2 weeks, i.e., topical prednisolone acetate 1%, 1 drop six times a day for 1 week followed by three times a day for 1 week. All patients underwent capillary fasting blood sugar (FBS) test at the following time points: before the start of surgery, 1-week postoperative, 1-month postoperative, and HbA1c at 3 months postoperative. Results: Forty nondiabetic patients (Group A) and 40 well-controlled diabetic patients (Group B) were included in the study. Group A showed a statistically significant increase when 1-week preoperative FBS level (105.9 ± 13.3) was compared with 1-week postoperative (114.42 ± 15.6) which returned to the pretreatment level (102.92 ± 8.9) on 1-month follow-up. In Group B, 1-week preoperative (126.05 ± 31.2) and 1-week postoperative FBS levels (126.37 ± 19.5) were comparable. Conclusion: Topical prednisolone acetate can be safely used as a short-term routine postcataract surgery regimen in nondiabetics and diabetics with good glycemic control, without a significant increase in blood sugar levels.https://journals.lww.com/10.4103/jcor.jcor_95_24blood sugarcataract surgerytopical prednisolone acetate |
| spellingShingle | Archana Bhat Prajakta Paritekar Y. Umesh Effect of prednisolone acetate eye drops on blood glucose profile in Indian population Journal of Clinical Ophthalmology and Research blood sugar cataract surgery topical prednisolone acetate |
| title | Effect of prednisolone acetate eye drops on blood glucose profile in Indian population |
| title_full | Effect of prednisolone acetate eye drops on blood glucose profile in Indian population |
| title_fullStr | Effect of prednisolone acetate eye drops on blood glucose profile in Indian population |
| title_full_unstemmed | Effect of prednisolone acetate eye drops on blood glucose profile in Indian population |
| title_short | Effect of prednisolone acetate eye drops on blood glucose profile in Indian population |
| title_sort | effect of prednisolone acetate eye drops on blood glucose profile in indian population |
| topic | blood sugar cataract surgery topical prednisolone acetate |
| url | https://journals.lww.com/10.4103/jcor.jcor_95_24 |
| work_keys_str_mv | AT archanabhat effectofprednisoloneacetateeyedropsonbloodglucoseprofileinindianpopulation AT prajaktaparitekar effectofprednisoloneacetateeyedropsonbloodglucoseprofileinindianpopulation AT yumesh effectofprednisoloneacetateeyedropsonbloodglucoseprofileinindianpopulation |