Effect of prednisolone acetate eye drops on blood glucose profile in Indian population
Background: One of the common indications of topical steroids is to control postoperative inflammation. This study aims to evaluate changes in blood glucose concentrations in diabetic and nondiabetic patients treated with a postoperative regimen of 1% topical prednisolone acetate after cataract surg...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Clinical Ophthalmology and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_95_24 |
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| Summary: | Background:
One of the common indications of topical steroids is to control postoperative inflammation. This study aims to evaluate changes in blood glucose concentrations in diabetic and nondiabetic patients treated with a postoperative regimen of 1% topical prednisolone acetate after cataract surgery.
Materials and Methods:
Prospective, observational cohort study conducted in a tertiary eye care hospital in South India from August 2022 to May 2023. Nondiabetics (Group A) and diabetics with good glycemic control, i.e., glycated hemoglobin (HbA1c) <7% (Group B) undergoing routine uneventful cataract surgery by a single surgeon were included in the study. All patients were prescribed the same regimen of topical corticosteroids after cataract surgery for 2 weeks, i.e., topical prednisolone acetate 1%, 1 drop six times a day for 1 week followed by three times a day for 1 week. All patients underwent capillary fasting blood sugar (FBS) test at the following time points: before the start of surgery, 1-week postoperative, 1-month postoperative, and HbA1c at 3 months postoperative.
Results:
Forty nondiabetic patients (Group A) and 40 well-controlled diabetic patients (Group B) were included in the study. Group A showed a statistically significant increase when 1-week preoperative FBS level (105.9 ± 13.3) was compared with 1-week postoperative (114.42 ± 15.6) which returned to the pretreatment level (102.92 ± 8.9) on 1-month follow-up. In Group B, 1-week preoperative (126.05 ± 31.2) and 1-week postoperative FBS levels (126.37 ± 19.5) were comparable.
Conclusion:
Topical prednisolone acetate can be safely used as a short-term routine postcataract surgery regimen in nondiabetics and diabetics with good glycemic control, without a significant increase in blood sugar levels. |
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| ISSN: | 2320-3897 2320-3900 |