Inhalation toxicity of (1→3)-β-D glucan: recent advances
To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all typ...
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791587 |
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| _version_ | 1832563542021111808 |
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| author | Birgitta Fogelmark Margareta Sjöstrand David Williams Ragnar Rylander |
| author_facet | Birgitta Fogelmark Margareta Sjöstrand David Williams Ragnar Rylander |
| author_sort | Birgitta Fogelmark |
| collection | DOAJ |
| description | To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all types of cells were increased after 24 h. A simultaneous exposure to curdlan reduced this increase in a dose-related fashion. The results suggest that (1→3)-β-D-glucan-related acute injury to the lung is induced by mechanisms other than those induced by inflammagenic agents such as endotoxin. |
| format | Article |
| id | doaj-art-14dd182499ce46dd88ab35492bce926e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-14dd182499ce46dd88ab35492bce926e2025-02-03T01:13:12ZengWileyMediators of Inflammation0962-93511466-18611997-01-016426326510.1080/09629359791587Inhalation toxicity of (1→3)-β-D glucan: recent advancesBirgitta Fogelmark0Margareta Sjöstrand1David Williams2Ragnar Rylander3Department of Environmental Medicine, University of Gothenburg, Medicinaregatan 16, Gothenburg S-413 90, SwedenDepartment of Environmental Medicine, University of Gothenburg, Medicinaregatan 16, Gothenburg S-413 90, SwedenDepartment of Surgery, James H. Quillen College of Medicine, Johnson City, Tennessee, USADepartment of Environmental Medicine, University of Gothenburg, Medicinaregatan 16, Gothenburg S-413 90, SwedenTo investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all types of cells were increased after 24 h. A simultaneous exposure to curdlan reduced this increase in a dose-related fashion. The results suggest that (1→3)-β-D-glucan-related acute injury to the lung is induced by mechanisms other than those induced by inflammagenic agents such as endotoxin.http://dx.doi.org/10.1080/09629359791587 |
| spellingShingle | Birgitta Fogelmark Margareta Sjöstrand David Williams Ragnar Rylander Inhalation toxicity of (1→3)-β-D glucan: recent advances Mediators of Inflammation |
| title | Inhalation toxicity of (1→3)-β-D glucan: recent advances |
| title_full | Inhalation toxicity of (1→3)-β-D glucan: recent advances |
| title_fullStr | Inhalation toxicity of (1→3)-β-D glucan: recent advances |
| title_full_unstemmed | Inhalation toxicity of (1→3)-β-D glucan: recent advances |
| title_short | Inhalation toxicity of (1→3)-β-D glucan: recent advances |
| title_sort | inhalation toxicity of 1 3 β d glucan recent advances |
| url | http://dx.doi.org/10.1080/09629359791587 |
| work_keys_str_mv | AT birgittafogelmark inhalationtoxicityof13bdglucanrecentadvances AT margaretasjostrand inhalationtoxicityof13bdglucanrecentadvances AT davidwilliams inhalationtoxicityof13bdglucanrecentadvances AT ragnarrylander inhalationtoxicityof13bdglucanrecentadvances |