Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM
Objective. To investigate the relationship between alcohol consumption and diabetic lower extremity arterial disease (LEAD) in hospitalized patients with type 2 diabetes mellitus (T2DM). Methods. We evaluated 138 hospitalized patients with T2DM who consumed alcohol and 833 who did not. We used prope...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8756978 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551166143102976 |
|---|---|
| author | Shanshan Yang Shuang Wang Bo Yang Jinliang Zheng Yuping Cai Zhengguo Yang |
| author_facet | Shanshan Yang Shuang Wang Bo Yang Jinliang Zheng Yuping Cai Zhengguo Yang |
| author_sort | Shanshan Yang |
| collection | DOAJ |
| description | Objective. To investigate the relationship between alcohol consumption and diabetic lower extremity arterial disease (LEAD) in hospitalized patients with type 2 diabetes mellitus (T2DM). Methods. We evaluated 138 hospitalized patients with T2DM who consumed alcohol and 833 who did not. We used propensity score matching to reduce the confounding bias between groups. Additionally, a logistic regression analysis was performed with the matched data to evaluate the LEAD risk. Results. In total, 119 pairs of patients who did and did not consume alcohol were matched. According to the logistic regression analysis, patients who consumed >8 U of alcohol/day had a higher risk of LEAD (odds ratio (OR): 6.35, 95% confidence interval (CI): 1.78–22.65) than patients who did not consume alcohol. Additionally, after adjusting for age, gender, region, occupation, smoking status, body mass index, weight change, and duration of diabetes, the OR of peripheral artery disease after >20 years of alcohol consumption was 3.48 (95% CI: 1.09–11.15). Furthermore, we observed a significant dose-response relationship between alcohol consumption and LEAD. Conclusions. Alcohol consumption may be a risk factor of LEAD in patients with T2DM. Patients with T2DM should be advised to stop drinking, to prevent the onset of LEAD. |
| format | Article |
| id | doaj-art-14dc42e0809b4edd82d632c6033ca533 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-14dc42e0809b4edd82d632c6033ca5332025-02-03T06:04:48ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/87569788756978Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DMShanshan Yang0Shuang Wang1Bo Yang2Jinliang Zheng3Yuping Cai4Zhengguo Yang5Institute of Geriatrics, Beijing Key Laboratory of Ageing and Geriatrics, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaDepartment of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, ChinaDepartment of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, ChinaDepartment of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, ChinaDepartment of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, ChinaDepartment of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, ChinaObjective. To investigate the relationship between alcohol consumption and diabetic lower extremity arterial disease (LEAD) in hospitalized patients with type 2 diabetes mellitus (T2DM). Methods. We evaluated 138 hospitalized patients with T2DM who consumed alcohol and 833 who did not. We used propensity score matching to reduce the confounding bias between groups. Additionally, a logistic regression analysis was performed with the matched data to evaluate the LEAD risk. Results. In total, 119 pairs of patients who did and did not consume alcohol were matched. According to the logistic regression analysis, patients who consumed >8 U of alcohol/day had a higher risk of LEAD (odds ratio (OR): 6.35, 95% confidence interval (CI): 1.78–22.65) than patients who did not consume alcohol. Additionally, after adjusting for age, gender, region, occupation, smoking status, body mass index, weight change, and duration of diabetes, the OR of peripheral artery disease after >20 years of alcohol consumption was 3.48 (95% CI: 1.09–11.15). Furthermore, we observed a significant dose-response relationship between alcohol consumption and LEAD. Conclusions. Alcohol consumption may be a risk factor of LEAD in patients with T2DM. Patients with T2DM should be advised to stop drinking, to prevent the onset of LEAD.http://dx.doi.org/10.1155/2017/8756978 |
| spellingShingle | Shanshan Yang Shuang Wang Bo Yang Jinliang Zheng Yuping Cai Zhengguo Yang Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM Journal of Diabetes Research |
| title | Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM |
| title_full | Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM |
| title_fullStr | Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM |
| title_full_unstemmed | Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM |
| title_short | Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM |
| title_sort | alcohol consumption is a risk factor for lower extremity arterial disease in chinese patients with t2dm |
| url | http://dx.doi.org/10.1155/2017/8756978 |
| work_keys_str_mv | AT shanshanyang alcoholconsumptionisariskfactorforlowerextremityarterialdiseaseinchinesepatientswitht2dm AT shuangwang alcoholconsumptionisariskfactorforlowerextremityarterialdiseaseinchinesepatientswitht2dm AT boyang alcoholconsumptionisariskfactorforlowerextremityarterialdiseaseinchinesepatientswitht2dm AT jinliangzheng alcoholconsumptionisariskfactorforlowerextremityarterialdiseaseinchinesepatientswitht2dm AT yupingcai alcoholconsumptionisariskfactorforlowerextremityarterialdiseaseinchinesepatientswitht2dm AT zhengguoyang alcoholconsumptionisariskfactorforlowerextremityarterialdiseaseinchinesepatientswitht2dm |