An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment
Oxidative stress that is induced by excessive reactive oxygen species (ROS) is considered to be a key pathophysiological mechanism of inflammatory bowel disease (IBD), and restoring redox homeostasis in the inflammatory region by eliminating ROS is an effective way to treat IBD. Herein, ultrasmall A...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2025-01-01
|
| Series: | Fundamental Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325822002916 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583000065310720 |
|---|---|
| author | Fei Wang Qianhui Li Tingting Xu Zhu Li Yongxin Jiang Yan Ma Xiaohu Li Wanni Wang Haisheng Qian |
| author_facet | Fei Wang Qianhui Li Tingting Xu Zhu Li Yongxin Jiang Yan Ma Xiaohu Li Wanni Wang Haisheng Qian |
| author_sort | Fei Wang |
| collection | DOAJ |
| description | Oxidative stress that is induced by excessive reactive oxygen species (ROS) is considered to be a key pathophysiological mechanism of inflammatory bowel disease (IBD), and restoring redox homeostasis in the inflammatory region by eliminating ROS is an effective way to treat IBD. Herein, ultrasmall Au25 nanoclusters (Au25 NCs) were synthesized using a simple improved protocol, which has good physiological stability and biosafety and can be noninvasively monitored by clinical computed tomography (CT) after oral administration. Au25 NCs can eliminate ROS such as ABTS radicals, superoxide free radicals (•O2−), and hydroxyl free radicals (•OH), upregulate the expression level of antioxidant enzymes, inhibit the expression of proinflammatory cytokines, and finally interrupt the inflammatory circuit of IBD to achieve the effective prevention and delayed treatment of IBD. This work will demonstrate the protective effect of Au25 NCs on IBD in living animals, which suggests a new nanomedicine strategy for IBD treatment. |
| format | Article |
| id | doaj-art-14dc25ca37cf44609adf89e8cb5c921d |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-14dc25ca37cf44609adf89e8cb5c921d2025-01-29T05:02:25ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-0151381390An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatmentFei Wang0Qianhui Li1Tingting Xu2Zhu Li3Yongxin Jiang4Yan Ma5Xiaohu Li6Wanni Wang7Haisheng Qian8Guangdong Provincial Key Laboratory of Digestive Cancer Research and The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, ChinaGuangdong Provincial Key Laboratory of Digestive Cancer Research and The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, ChinaSchool of Basic Medical Sciences Anhui Medical University, Hefei 230032, ChinaGuangdong Provincial Key Laboratory of Digestive Cancer Research and The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, ChinaSchool of Basic Medical Sciences Anhui Medical University, Hefei 230032, ChinaSchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei 230032, China; Corresponding authors.School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei 230032, China; Corresponding authors.School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei 230032, China; Corresponding authors.Oxidative stress that is induced by excessive reactive oxygen species (ROS) is considered to be a key pathophysiological mechanism of inflammatory bowel disease (IBD), and restoring redox homeostasis in the inflammatory region by eliminating ROS is an effective way to treat IBD. Herein, ultrasmall Au25 nanoclusters (Au25 NCs) were synthesized using a simple improved protocol, which has good physiological stability and biosafety and can be noninvasively monitored by clinical computed tomography (CT) after oral administration. Au25 NCs can eliminate ROS such as ABTS radicals, superoxide free radicals (•O2−), and hydroxyl free radicals (•OH), upregulate the expression level of antioxidant enzymes, inhibit the expression of proinflammatory cytokines, and finally interrupt the inflammatory circuit of IBD to achieve the effective prevention and delayed treatment of IBD. This work will demonstrate the protective effect of Au25 NCs on IBD in living animals, which suggests a new nanomedicine strategy for IBD treatment.http://www.sciencedirect.com/science/article/pii/S2667325822002916Inflammatory bowel diseaseOxidative stressReactive oxygen speciesAu nanoclustersROS scavengers |
| spellingShingle | Fei Wang Qianhui Li Tingting Xu Zhu Li Yongxin Jiang Yan Ma Xiaohu Li Wanni Wang Haisheng Qian An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment Fundamental Research Inflammatory bowel disease Oxidative stress Reactive oxygen species Au nanoclusters ROS scavengers |
| title | An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment |
| title_full | An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment |
| title_fullStr | An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment |
| title_full_unstemmed | An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment |
| title_short | An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment |
| title_sort | orally administered gold nanocluster with ros scavenging for inflammatory bowel disease treatment |
| topic | Inflammatory bowel disease Oxidative stress Reactive oxygen species Au nanoclusters ROS scavengers |
| url | http://www.sciencedirect.com/science/article/pii/S2667325822002916 |
| work_keys_str_mv | AT feiwang anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT qianhuili anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT tingtingxu anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT zhuli anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT yongxinjiang anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT yanma anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT xiaohuli anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT wanniwang anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT haishengqian anorallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT feiwang orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT qianhuili orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT tingtingxu orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT zhuli orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT yongxinjiang orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT yanma orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT xiaohuli orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT wanniwang orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment AT haishengqian orallyadministeredgoldnanoclusterwithrosscavengingforinflammatoryboweldiseasetreatment |