Study on the pathogenesis of pathophysiological changes of burn systemic infection
The present prospective study showed that incidence of systemic infection in severe burn patients was 30.9%. Toxic shock and multiple organ failure (MOF) developed in all patients with uncontrolled systemic infection. Both morbidity and mortality of MOF were 76.5%. In the infection group, plasma TXB...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000553 |
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| _version_ | 1832562305853816832 |
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| author | Li Ao (Ngao) Huang Yuesheng Yang Zongcheng |
| author_facet | Li Ao (Ngao) Huang Yuesheng Yang Zongcheng |
| author_sort | Li Ao (Ngao) |
| collection | DOAJ |
| description | The present prospective study showed that incidence of systemic infection in severe burn patients was 30.9%. Toxic shock and multiple organ failure (MOF) developed in all patients with uncontrolled systemic infection. Both morbidity and mortality of MOF were 76.5%. In the infection group, plasma TXB2 and TXB2/6-keto-PGF1α ratio increased markedly. Their changes were closely correlated with the clinical course and deterioration of systemic infection. Circulatory platelet aggregate ratio decreased significantly, while myocardiac enzyme spectrum greatly increased. Thrombi were observed in visceral tissues from patients dying of systemic infection. These suggested that TXA2/PGI2. imbalance promoting microaggregate and thrombus formation may be one of the pathogenic effects of toxic shock and MOF in burn patients. |
| format | Article |
| id | doaj-art-14d5c0dd864e4fd2b866d4706a486cd4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-14d5c0dd864e4fd2b866d4706a486cd42025-02-03T01:22:54ZengWileyMediators of Inflammation0962-93511466-18611992-01-011637137410.1155/S0962935192000553Study on the pathogenesis of pathophysiological changes of burn systemic infectionLi Ao (Ngao)0Huang Yuesheng1Yang Zongcheng2Burn Institute, Southwestern Hospital, Third Military Medical College of PLA, Sichuan, Chongqing 630038, ChinaBurn Institute, Southwestern Hospital, Third Military Medical College of PLA, Sichuan, Chongqing 630038, ChinaBurn Institute, Southwestern Hospital, Third Military Medical College of PLA, Sichuan, Chongqing 630038, ChinaThe present prospective study showed that incidence of systemic infection in severe burn patients was 30.9%. Toxic shock and multiple organ failure (MOF) developed in all patients with uncontrolled systemic infection. Both morbidity and mortality of MOF were 76.5%. In the infection group, plasma TXB2 and TXB2/6-keto-PGF1α ratio increased markedly. Their changes were closely correlated with the clinical course and deterioration of systemic infection. Circulatory platelet aggregate ratio decreased significantly, while myocardiac enzyme spectrum greatly increased. Thrombi were observed in visceral tissues from patients dying of systemic infection. These suggested that TXA2/PGI2. imbalance promoting microaggregate and thrombus formation may be one of the pathogenic effects of toxic shock and MOF in burn patients.http://dx.doi.org/10.1155/S0962935192000553 |
| spellingShingle | Li Ao (Ngao) Huang Yuesheng Yang Zongcheng Study on the pathogenesis of pathophysiological changes of burn systemic infection Mediators of Inflammation |
| title | Study on the pathogenesis of pathophysiological changes of burn systemic infection |
| title_full | Study on the pathogenesis of pathophysiological changes of burn systemic infection |
| title_fullStr | Study on the pathogenesis of pathophysiological changes of burn systemic infection |
| title_full_unstemmed | Study on the pathogenesis of pathophysiological changes of burn systemic infection |
| title_short | Study on the pathogenesis of pathophysiological changes of burn systemic infection |
| title_sort | study on the pathogenesis of pathophysiological changes of burn systemic infection |
| url | http://dx.doi.org/10.1155/S0962935192000553 |
| work_keys_str_mv | AT liaongao studyonthepathogenesisofpathophysiologicalchangesofburnsystemicinfection AT huangyuesheng studyonthepathogenesisofpathophysiologicalchangesofburnsystemicinfection AT yangzongcheng studyonthepathogenesisofpathophysiologicalchangesofburnsystemicinfection |