The Role of Lipid Rafts in Cancer Cell Adhesion and Migration
Lipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular functions including the regulation of cell adhesion and membrane signaling through proteins within lipid rafts. The dynamic features of the cancer c...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/763283 |
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| _version_ | 1832553379868442624 |
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| author | Toshiyuki Murai |
| author_facet | Toshiyuki Murai |
| author_sort | Toshiyuki Murai |
| collection | DOAJ |
| description | Lipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular functions including the regulation of cell adhesion and membrane signaling through proteins within lipid rafts. The dynamic features of the cancer cell surface may modulate the malignant phenotype of cancer, including adhesion disorders and aggressive phenotypes of migration and invasion. Recently, it was demonstrated that lipid rafts play critical roles in cancer cell adhesion and migration. This article summarizes the important roles of lipid rafts in cancer cell adhesion and migration, with a focus on the current state of knowledge. This article will improve the understanding of cancer progression and lead to the development of novel targets for cancer therapy. |
| format | Article |
| id | doaj-art-14d3b5c88970475dbfac7d350d47aff1 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-14d3b5c88970475dbfac7d350d47aff12025-02-03T05:53:59ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/763283763283The Role of Lipid Rafts in Cancer Cell Adhesion and MigrationToshiyuki Murai0Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Osaka, Suita 565-0871, JapanLipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular functions including the regulation of cell adhesion and membrane signaling through proteins within lipid rafts. The dynamic features of the cancer cell surface may modulate the malignant phenotype of cancer, including adhesion disorders and aggressive phenotypes of migration and invasion. Recently, it was demonstrated that lipid rafts play critical roles in cancer cell adhesion and migration. This article summarizes the important roles of lipid rafts in cancer cell adhesion and migration, with a focus on the current state of knowledge. This article will improve the understanding of cancer progression and lead to the development of novel targets for cancer therapy.http://dx.doi.org/10.1155/2012/763283 |
| spellingShingle | Toshiyuki Murai The Role of Lipid Rafts in Cancer Cell Adhesion and Migration International Journal of Cell Biology |
| title | The Role of Lipid Rafts in Cancer Cell Adhesion and Migration |
| title_full | The Role of Lipid Rafts in Cancer Cell Adhesion and Migration |
| title_fullStr | The Role of Lipid Rafts in Cancer Cell Adhesion and Migration |
| title_full_unstemmed | The Role of Lipid Rafts in Cancer Cell Adhesion and Migration |
| title_short | The Role of Lipid Rafts in Cancer Cell Adhesion and Migration |
| title_sort | role of lipid rafts in cancer cell adhesion and migration |
| url | http://dx.doi.org/10.1155/2012/763283 |
| work_keys_str_mv | AT toshiyukimurai theroleoflipidraftsincancercelladhesionandmigration AT toshiyukimurai roleoflipidraftsincancercelladhesionandmigration |