Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia?
Primary progressive aphasia (PPA) corresponds to the gradual degeneration of language which can occur as nonfluent/agrammatic PPA, semantic variant PPA or logopenic variant PPA. We describe the clinical evolution of a patient with PPA presenting jargon aphasia as a late feature. At the onset of the...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-2012-110218 |
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| author | Paolo Caffarra Simona Gardini Stefano Cappa Francesca Dieci Letizia Concari Federica Barocco Caterina Ghetti Livia Ruffini Guido Dalla Rosa Prati |
| author_facet | Paolo Caffarra Simona Gardini Stefano Cappa Francesca Dieci Letizia Concari Federica Barocco Caterina Ghetti Livia Ruffini Guido Dalla Rosa Prati |
| author_sort | Paolo Caffarra |
| collection | DOAJ |
| description | Primary progressive aphasia (PPA) corresponds to the gradual degeneration of language which can occur as nonfluent/agrammatic PPA, semantic variant PPA or logopenic variant PPA. We describe the clinical evolution of a patient with PPA presenting jargon aphasia as a late feature. At the onset of the disease (ten years ago) the patient showed anomia and executive deficits, followed later on by phonemic paraphasias and neologisms, deficits in verbal short-term memory, naming, verbal and semantic fluency. At recent follow-up the patient developed an unintelligible jargon with both semantic and neologistic errors, as well as with severe deficit of comprehension which precluded any further neuropsychological assessment. Compared to healthy controls, FDG-PET showed a hypometabolism in the left angular and middle temporal gyri, precuneus, caudate, posterior cingulate, middle frontal gyrus, and bilaterally in the superior temporal and inferior frontal gyri. The clinical and neuroimaging profile seems to support the hypothesis that the patient developed a late feature of logopenic variant PPA characterized by jargonaphasia and associated with superior temporal and parietal dysfunction. |
| format | Article |
| id | doaj-art-14cf0ef5b6054609af87ae86e3328b87 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-14cf0ef5b6054609af87ae86e3328b872025-02-03T01:01:55ZengWileyBehavioural Neurology0953-41801875-85842013-01-01261-2899310.3233/BEN-2012-110218Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia?Paolo Caffarra0Simona Gardini1Stefano Cappa2Francesca Dieci3Letizia Concari4Federica Barocco5Caterina Ghetti6Livia Ruffini7Guido Dalla Rosa Prati8Department of Neuroscience, University of Parma, Parma, ItalyDepartment of Neuroscience, University of Parma, Parma, ItalyDepartment of Clinical Neuroscience, Vita-Salute San Raffaele Hospital, Milan, ItalyOutpatient Clinic for the Diagnosis and Therapy of Cognitive Disorders, AUSL, Parma, ItalyDepartment of Neuroscience, University of Parma, Parma, ItalyDepartment of Neuroscience, University of Parma, Parma, ItalyMedical Physic Department, Azienda Ospedaliero-Universitaria, Parma, ItalyDepartment of Nuclear Medicine, Azienda Ospedaliero-Universitaria, Parma, ItalyPoliambulatorio Dalla Rosa Prati, Centro Diagnostico Europeo, Parma, ItalyPrimary progressive aphasia (PPA) corresponds to the gradual degeneration of language which can occur as nonfluent/agrammatic PPA, semantic variant PPA or logopenic variant PPA. We describe the clinical evolution of a patient with PPA presenting jargon aphasia as a late feature. At the onset of the disease (ten years ago) the patient showed anomia and executive deficits, followed later on by phonemic paraphasias and neologisms, deficits in verbal short-term memory, naming, verbal and semantic fluency. At recent follow-up the patient developed an unintelligible jargon with both semantic and neologistic errors, as well as with severe deficit of comprehension which precluded any further neuropsychological assessment. Compared to healthy controls, FDG-PET showed a hypometabolism in the left angular and middle temporal gyri, precuneus, caudate, posterior cingulate, middle frontal gyrus, and bilaterally in the superior temporal and inferior frontal gyri. The clinical and neuroimaging profile seems to support the hypothesis that the patient developed a late feature of logopenic variant PPA characterized by jargonaphasia and associated with superior temporal and parietal dysfunction.http://dx.doi.org/10.3233/BEN-2012-110218 |
| spellingShingle | Paolo Caffarra Simona Gardini Stefano Cappa Francesca Dieci Letizia Concari Federica Barocco Caterina Ghetti Livia Ruffini Guido Dalla Rosa Prati Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia? Behavioural Neurology |
| title | Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia? |
| title_full | Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia? |
| title_fullStr | Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia? |
| title_full_unstemmed | Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia? |
| title_short | Degenerative Jargon Aphasia: Unusual Progression of Logopenic/Phonological Progressive Aphasia? |
| title_sort | degenerative jargon aphasia unusual progression of logopenic phonological progressive aphasia |
| url | http://dx.doi.org/10.3233/BEN-2012-110218 |
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