Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System
The polyomaviruses are small DNA viruses that can establish latency in the human host. The name polyomavirus is derived from the Greek roots poly-, which means “many,” and -oma, which means “tumours.” These viruses were originally isolated in mouse (mPyV) and in monkey (SV40). In 1971, the first hum...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/542092 |
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| _version_ | 1832561199721480192 |
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| author | Serena Delbue Manola Comar Pasquale Ferrante |
| author_facet | Serena Delbue Manola Comar Pasquale Ferrante |
| author_sort | Serena Delbue |
| collection | DOAJ |
| description | The polyomaviruses are small DNA viruses that can establish latency in the human host. The name polyomavirus is derived from the Greek roots poly-, which means “many,” and -oma, which means “tumours.” These viruses were originally isolated in mouse (mPyV) and in monkey (SV40). In 1971, the first human polyomaviruses BK and JC were isolated and subsequently demonstrated to be ubiquitous in the human population. To date, at least nine members of the Polyomaviridae family have been identified, some of them playing an etiological role in malignancies in immunosuppressed patients. Here, we describe the biology of human polyomaviruses, their nonmalignant and malignant potentials ability, and their relationship with the host immune response. |
| format | Article |
| id | doaj-art-14a04a31622e4911a1eefb562265cb09 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-14a04a31622e4911a1eefb562265cb092025-02-03T01:25:38ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/542092542092Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune SystemSerena Delbue0Manola Comar1Pasquale Ferrante2Laboratory of Transkìlational Research, Health Science Foundation “Ettore Sansavini”, Corso Garibaldi, 11-48022 Lugo, ItalyDepartment of Reproductive, Developmental and Public Health Sciences, University of Trieste, Via dell’Istria 65/1, 34137 Trieste, ItalyDepartment of Public Health, Microbiology, Virology, University of Milano, Via Pascal 36, 20133 Milan, ItalyThe polyomaviruses are small DNA viruses that can establish latency in the human host. The name polyomavirus is derived from the Greek roots poly-, which means “many,” and -oma, which means “tumours.” These viruses were originally isolated in mouse (mPyV) and in monkey (SV40). In 1971, the first human polyomaviruses BK and JC were isolated and subsequently demonstrated to be ubiquitous in the human population. To date, at least nine members of the Polyomaviridae family have been identified, some of them playing an etiological role in malignancies in immunosuppressed patients. Here, we describe the biology of human polyomaviruses, their nonmalignant and malignant potentials ability, and their relationship with the host immune response.http://dx.doi.org/10.1155/2012/542092 |
| spellingShingle | Serena Delbue Manola Comar Pasquale Ferrante Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System Clinical and Developmental Immunology |
| title | Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System |
| title_full | Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System |
| title_fullStr | Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System |
| title_full_unstemmed | Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System |
| title_short | Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System |
| title_sort | review on the relationship between human polyomaviruses associated tumors and host immune system |
| url | http://dx.doi.org/10.1155/2012/542092 |
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