Poor efficacy of the combination of clarithromycin, amikacin, and cefoxitin against Mycobacterium abscessus in the hollow fiber infection model

Poor efficacy of the combination of clarithromycin, amikacin, and cefoxitin against Mycobacterium abscessus in the hollow fiber infection model

Abstract Background Mycobacterium abscessus (MABS) causes difficult-to-treat pulmonary and extra-pulmonary infections. A combination therapy comprising amikacin, cefoxitin, and a macrolide agent is recommended, but its antimicrobial activity and clinical efficacy is uncertain. Inducible resistance t...

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Main Authors: Etienne Vignaud, Sylvain Goutelle, Charlotte Genestet, Jérôme Guitton, Sabine Cohen, Chloé Bourg, Aurore Durand, Laura Lebouteiller, Albin Bernard, Caroline Richet, Oana Dumitrescu, Elisabeth Hodille
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Annals of Clinical Microbiology and Antimicrobials
Subjects:
Mycobacterium abscessus
Hollow-fiber system
Hollow-fiber infection model
Clarithromycin
Amikacin
Cefoxitin
Online Access:https://doi.org/10.1186/s12941-025-00776-w
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https://doi.org/10.1186/s12941-025-00776-w

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