Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and Azacarbazole
A study directed towards exploring the temperature-dependent reactivity of the chlorine atoms of 2,4,6-trichloro-s-triazine (TCT) in the nucleophilic displacement reaction, allowed a facile replacement of its chlorine atoms in succession with (i) N-amino methyl substituted isatin-3-hydrazones, (ii...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/925439 |
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| author | Sonika Jain Anamika Sharma Meenakshi Agrawal Swapnil Sharma Jaya Dwivedi D. Kishore |
| author_facet | Sonika Jain Anamika Sharma Meenakshi Agrawal Swapnil Sharma Jaya Dwivedi D. Kishore |
| author_sort | Sonika Jain |
| collection | DOAJ |
| description | A study directed towards exploring the temperature-dependent reactivity of the chlorine atoms of 2,4,6-trichloro-s-triazine (TCT) in the nucleophilic displacement reaction, allowed a facile replacement of its chlorine atoms in succession with (i) N-amino methyl substituted isatin-3-hydrazones, (ii) N1-substituted-4-amino benzene sulphonamides, and (iii) 8-amino-4-oxo-N-benzyl-azacarbazole to produce the corresponding 2,4,6-trisubstituted-s-triazine, namely; 2-(N-amino methyl substituted isatin-3-hydrazinyl)-4-(N1-substituted-4′-amino benzenesulfonamidyl)-6-(8′-amino-4′-oxo-N-benzylazacarbazolyl)-1,3,5-triazine derivatives in acceptable yields. The compounds prepared were further evaluated for their antibacterial activity against E. coli and B. subtilis and antifungal activities against A. niger and A. flavus, and some of them showed promising activity profile. |
| format | Article |
| id | doaj-art-148afd6248734d45af5d4c58214a6316 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-148afd6248734d45af5d4c58214a63162025-02-03T05:43:53ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/925439925439Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and AzacarbazoleSonika Jain0Anamika Sharma1Meenakshi Agrawal2Swapnil Sharma3Jaya Dwivedi4D. Kishore5Department of Chemistry, Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaA study directed towards exploring the temperature-dependent reactivity of the chlorine atoms of 2,4,6-trichloro-s-triazine (TCT) in the nucleophilic displacement reaction, allowed a facile replacement of its chlorine atoms in succession with (i) N-amino methyl substituted isatin-3-hydrazones, (ii) N1-substituted-4-amino benzene sulphonamides, and (iii) 8-amino-4-oxo-N-benzyl-azacarbazole to produce the corresponding 2,4,6-trisubstituted-s-triazine, namely; 2-(N-amino methyl substituted isatin-3-hydrazinyl)-4-(N1-substituted-4′-amino benzenesulfonamidyl)-6-(8′-amino-4′-oxo-N-benzylazacarbazolyl)-1,3,5-triazine derivatives in acceptable yields. The compounds prepared were further evaluated for their antibacterial activity against E. coli and B. subtilis and antifungal activities against A. niger and A. flavus, and some of them showed promising activity profile.http://dx.doi.org/10.1155/2013/925439 |
| spellingShingle | Sonika Jain Anamika Sharma Meenakshi Agrawal Swapnil Sharma Jaya Dwivedi D. Kishore Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and Azacarbazole Journal of Chemistry |
| title | Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and Azacarbazole |
| title_full | Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and Azacarbazole |
| title_fullStr | Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and Azacarbazole |
| title_full_unstemmed | Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and Azacarbazole |
| title_short | Synthesis and Antimicrobial Evaluation of Some Novel Trisubstituted s-Triazine Derivatives Based on Isatinimino, Sulphonamido, and Azacarbazole |
| title_sort | synthesis and antimicrobial evaluation of some novel trisubstituted s triazine derivatives based on isatinimino sulphonamido and azacarbazole |
| url | http://dx.doi.org/10.1155/2013/925439 |
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