Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature
Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of a 59-year-old female with lactic acidosis who...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/534561 |
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| author | Farn Huei Chan Daniel Carl Laurel J. Lyckholm |
| author_facet | Farn Huei Chan Daniel Carl Laurel J. Lyckholm |
| author_sort | Farn Huei Chan |
| collection | DOAJ |
| description | Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of a 59-year-old female with lactic acidosis who was found to have aggressive B-cell lymphoma. There have been 29 cases of lymphoma induced lactic acidosis reported thus far; however all reported cases have abnormal vital signs or concomitant medical conditions that may lead to lactic acidosis. The pathogenesis of malignancy-induced lactic acidosis is not well understood; however associated factors include increased glycolysis, increased lactate production by cancer cells, and decreased hepatic clearance of lactate. When it occurs, lactic acidosis is a poor prognostic sign in these patients. Prompt diagnosis and treatment of underlying lymphoma or leukemia remains the only way to achieve complete resolution of lactic acidosis in these patients. |
| format | Article |
| id | doaj-art-147b6732f7f04541960112a71941470b |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-147b6732f7f04541960112a71941470b2025-02-03T01:07:00ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/534561534561Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the LiteratureFarn Huei Chan0Daniel Carl1Laurel J. Lyckholm2Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Internal Medicine, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA 23298, USALactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of a 59-year-old female with lactic acidosis who was found to have aggressive B-cell lymphoma. There have been 29 cases of lymphoma induced lactic acidosis reported thus far; however all reported cases have abnormal vital signs or concomitant medical conditions that may lead to lactic acidosis. The pathogenesis of malignancy-induced lactic acidosis is not well understood; however associated factors include increased glycolysis, increased lactate production by cancer cells, and decreased hepatic clearance of lactate. When it occurs, lactic acidosis is a poor prognostic sign in these patients. Prompt diagnosis and treatment of underlying lymphoma or leukemia remains the only way to achieve complete resolution of lactic acidosis in these patients.http://dx.doi.org/10.1155/2009/534561 |
| spellingShingle | Farn Huei Chan Daniel Carl Laurel J. Lyckholm Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature Case Reports in Medicine |
| title | Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature |
| title_full | Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature |
| title_fullStr | Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature |
| title_full_unstemmed | Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature |
| title_short | Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature |
| title_sort | severe lactic acidosis in a patient with b cell lymphoma a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2009/534561 |
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