The association between salivary oxytocin, age, and puberty in children with and without OCD
Abstract The oxytocin system has been thought to contribute to obsessive-compulsive disorder (OCD). Few studies, only involving adults, have investigated this hypothesis and have found inconsistent results regarding oxytocin system activity and OCD. We investigated whether salivary oxytocin concentr...
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| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-80194-8 |
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| author | Anna-Rosa Cecilie Mora-Jensen Line Katrine Harder Clemmensen Manja Gersholm Grønberg Eli R. Lebowitz Daniel S. Quintana Niklas Rye Jørgensen Charlotte Sewerin Larsen Lasse Kristoffer Bak Gitte Lund Christensen Linea Pretzmann Valdemar Uhre Sofie Heidenheim Christensen Camilla Uhre Nicoline Løcke Jepsen Korsbjerg Christine Lykke Thoustrup Julie Hagstrøm Melanie Ritter Kerstin Jessica Plessen Anne Katrine Pagsberg Nicole Nadine Lønfeldt |
| author_facet | Anna-Rosa Cecilie Mora-Jensen Line Katrine Harder Clemmensen Manja Gersholm Grønberg Eli R. Lebowitz Daniel S. Quintana Niklas Rye Jørgensen Charlotte Sewerin Larsen Lasse Kristoffer Bak Gitte Lund Christensen Linea Pretzmann Valdemar Uhre Sofie Heidenheim Christensen Camilla Uhre Nicoline Løcke Jepsen Korsbjerg Christine Lykke Thoustrup Julie Hagstrøm Melanie Ritter Kerstin Jessica Plessen Anne Katrine Pagsberg Nicole Nadine Lønfeldt |
| author_sort | Anna-Rosa Cecilie Mora-Jensen |
| collection | DOAJ |
| description | Abstract The oxytocin system has been thought to contribute to obsessive-compulsive disorder (OCD). Few studies, only involving adults, have investigated this hypothesis and have found inconsistent results regarding oxytocin system activity and OCD. We investigated whether salivary oxytocin concentrations differed between children and adolescents with and without OCD and qualified our comparative analysis by investigating the possible covariates age, pubertal stage, and sex. Participants included 113 children and adolescents (8–17 years) with OCD and 88 children and adolescents without any previous or current psychiatric disorder and their parents (254 parents included). Salivary oxytocin concentrations were measured in children and parents with enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using frequentist and Bayesian approaches. We found no evidence of a difference in mean salivary oxytocin concentrations between children and adolescents with and without OCD. Bayesian analysis indicated anecdotal to moderate support for the null hypothesis. We found an association between oxytocin and age and between oxytocin and pubertal stage, which by visual inspection of plots and post-hoc tests indicated nonlinear relationships. We found no association between oxytocin concentration and sex. Our findings do not suggest elevated oxytocin concentrations in pediatric OCD. Nonlinear changes in oxytocin across development show the importance of accounting for hormonal and behavioral changes during puberty. |
| format | Article |
| id | doaj-art-146a434a12244e448863dd3d23bc4d0b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-146a434a12244e448863dd3d23bc4d0b2025-01-26T12:35:18ZengNature PortfolioScientific Reports2045-23222024-11-0114111210.1038/s41598-024-80194-8The association between salivary oxytocin, age, and puberty in children with and without OCDAnna-Rosa Cecilie Mora-Jensen0Line Katrine Harder Clemmensen1Manja Gersholm Grønberg2Eli R. Lebowitz3Daniel S. Quintana4Niklas Rye Jørgensen5Charlotte Sewerin Larsen6Lasse Kristoffer Bak7Gitte Lund Christensen8Linea Pretzmann9Valdemar Uhre10Sofie Heidenheim Christensen11Camilla Uhre12Nicoline Løcke Jepsen Korsbjerg13Christine Lykke Thoustrup14Julie Hagstrøm15Melanie Ritter16Kerstin Jessica Plessen17Anne Katrine Pagsberg18Nicole Nadine Lønfeldt19Child and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHApplied Mathematics and Computer Science, Technical University of DenmarkApplied Mathematics and Computer Science, Technical University of DenmarkChild Study Center, Yale UniversityDepartment of Psychology, University of OsloDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Clinical Biochemistry, Copenhagen University Hospital - RigshospitaletDepartment of Clinical Biochemistry, Copenhagen University Hospital - RigshospitaletDepartment of Clinical Biochemistry, Copenhagen University Hospital - RigshospitaletChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHChild and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPHAbstract The oxytocin system has been thought to contribute to obsessive-compulsive disorder (OCD). Few studies, only involving adults, have investigated this hypothesis and have found inconsistent results regarding oxytocin system activity and OCD. We investigated whether salivary oxytocin concentrations differed between children and adolescents with and without OCD and qualified our comparative analysis by investigating the possible covariates age, pubertal stage, and sex. Participants included 113 children and adolescents (8–17 years) with OCD and 88 children and adolescents without any previous or current psychiatric disorder and their parents (254 parents included). Salivary oxytocin concentrations were measured in children and parents with enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using frequentist and Bayesian approaches. We found no evidence of a difference in mean salivary oxytocin concentrations between children and adolescents with and without OCD. Bayesian analysis indicated anecdotal to moderate support for the null hypothesis. We found an association between oxytocin and age and between oxytocin and pubertal stage, which by visual inspection of plots and post-hoc tests indicated nonlinear relationships. We found no association between oxytocin concentration and sex. Our findings do not suggest elevated oxytocin concentrations in pediatric OCD. Nonlinear changes in oxytocin across development show the importance of accounting for hormonal and behavioral changes during puberty.https://doi.org/10.1038/s41598-024-80194-8OxytocinObsessive-compulsive disorderChildrenAdolescentsPubertal stageAge |
| spellingShingle | Anna-Rosa Cecilie Mora-Jensen Line Katrine Harder Clemmensen Manja Gersholm Grønberg Eli R. Lebowitz Daniel S. Quintana Niklas Rye Jørgensen Charlotte Sewerin Larsen Lasse Kristoffer Bak Gitte Lund Christensen Linea Pretzmann Valdemar Uhre Sofie Heidenheim Christensen Camilla Uhre Nicoline Løcke Jepsen Korsbjerg Christine Lykke Thoustrup Julie Hagstrøm Melanie Ritter Kerstin Jessica Plessen Anne Katrine Pagsberg Nicole Nadine Lønfeldt The association between salivary oxytocin, age, and puberty in children with and without OCD Scientific Reports Oxytocin Obsessive-compulsive disorder Children Adolescents Pubertal stage Age |
| title | The association between salivary oxytocin, age, and puberty in children with and without OCD |
| title_full | The association between salivary oxytocin, age, and puberty in children with and without OCD |
| title_fullStr | The association between salivary oxytocin, age, and puberty in children with and without OCD |
| title_full_unstemmed | The association between salivary oxytocin, age, and puberty in children with and without OCD |
| title_short | The association between salivary oxytocin, age, and puberty in children with and without OCD |
| title_sort | association between salivary oxytocin age and puberty in children with and without ocd |
| topic | Oxytocin Obsessive-compulsive disorder Children Adolescents Pubertal stage Age |
| url | https://doi.org/10.1038/s41598-024-80194-8 |
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