Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury
Hepatic ischemia-reperfusion injury, fatty liver, liver fibrosis, liver peroxidative injury, and drug-induced liver injury are among the most common liver diseases. Mesenchymal stem cells (MSCs) possess multi-lineage differentiation potential and immunomodulatory functions. In the treatment of live...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-05-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12144 |
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| author | Shaolong Yang Juanyu Liu Jia Siang Khe Alvin Jiunn Hieng Lu Vuanghao Lim |
| author_facet | Shaolong Yang Juanyu Liu Jia Siang Khe Alvin Jiunn Hieng Lu Vuanghao Lim |
| author_sort | Shaolong Yang |
| collection | DOAJ |
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Hepatic ischemia-reperfusion injury, fatty liver, liver fibrosis, liver peroxidative injury, and drug-induced liver injury are among the most common liver diseases. Mesenchymal stem cells (MSCs) possess multi-lineage differentiation potential and immunomodulatory functions. In the treatment of liver injury, MSCs can promote repair through homing effects, direct differentiation into hepatocyte-like cells (HLCs), immunomodulation, and anti-fibrotic mechanisms. Clinically, MSCs contribute to liver injury repair either directly or indirectly via the secretion of exosomes. Beyond their reparative role, MSC-derived exosomes can also serve as molecular biomarkers for the diagnosis and prognosis of liver diseases [1]. Establishing higher-quality standards, robust auditing and evaluation systems, and conducting deeper mechanistic studies are essential prerequisites for the future clinical application of MSCs in the treatment of liver diseases.
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| format | Article |
| id | doaj-art-14511fdcf4584e05ab6d2ad78cb2dd4e |
| institution | Kabale University |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-14511fdcf4584e05ab6d2ad78cb2dd4e2025-08-20T03:52:39ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-05-0110.17305/bb.2025.12144Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injuryShaolong Yang0https://orcid.org/0000-0003-2682-3737Juanyu Liu1https://orcid.org/0009-0006-1296-9873Jia Siang Khe2https://orcid.org/0009-0001-9689-1674Alvin Jiunn Hieng Lu3https://orcid.org/0009-0005-0262-0275Vuanghao Lim4https://orcid.org/0000-0001-5081-0982Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam Kepala Batas, Penang, Malaysia; School of Nursing, Zhengzhou Railway Vocational & Technical College, Pengcheng Avenue, Zhengdong New District, Zhengzhou, Henan Province, ChinaDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaAdvanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam Kepala Batas, Penang, Malaysia Hepatic ischemia-reperfusion injury, fatty liver, liver fibrosis, liver peroxidative injury, and drug-induced liver injury are among the most common liver diseases. Mesenchymal stem cells (MSCs) possess multi-lineage differentiation potential and immunomodulatory functions. In the treatment of liver injury, MSCs can promote repair through homing effects, direct differentiation into hepatocyte-like cells (HLCs), immunomodulation, and anti-fibrotic mechanisms. Clinically, MSCs contribute to liver injury repair either directly or indirectly via the secretion of exosomes. Beyond their reparative role, MSC-derived exosomes can also serve as molecular biomarkers for the diagnosis and prognosis of liver diseases [1]. Establishing higher-quality standards, robust auditing and evaluation systems, and conducting deeper mechanistic studies are essential prerequisites for the future clinical application of MSCs in the treatment of liver diseases. https://www.bjbms.org/ojs/index.php/bjbms/article/view/12144Liver injurymesenchymal stem cellsMSCsexosomeshepatic fibrosis |
| spellingShingle | Shaolong Yang Juanyu Liu Jia Siang Khe Alvin Jiunn Hieng Lu Vuanghao Lim Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury Biomolecules & Biomedicine Liver injury mesenchymal stem cells MSCs exosomes hepatic fibrosis |
| title | Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury |
| title_full | Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury |
| title_fullStr | Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury |
| title_full_unstemmed | Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury |
| title_short | Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury |
| title_sort | emerging insights into mesenchymal stem cells and exosome based therapies for liver injury |
| topic | Liver injury mesenchymal stem cells MSCs exosomes hepatic fibrosis |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12144 |
| work_keys_str_mv | AT shaolongyang emerginginsightsintomesenchymalstemcellsandexosomebasedtherapiesforliverinjury AT juanyuliu emerginginsightsintomesenchymalstemcellsandexosomebasedtherapiesforliverinjury AT jiasiangkhe emerginginsightsintomesenchymalstemcellsandexosomebasedtherapiesforliverinjury AT alvinjiunnhienglu emerginginsightsintomesenchymalstemcellsandexosomebasedtherapiesforliverinjury AT vuanghaolim emerginginsightsintomesenchymalstemcellsandexosomebasedtherapiesforliverinjury |