Oxi-Inflamm-Aging: a New Theory with Practical Implications
Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune <em>dysregulation</em> leads to a <em>chronic low-grade inflammatory state</em> in aging. This is the basis of the new integrative the...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2016-10-01
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| Series: | Medisur |
| Subjects: | |
| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/3280 |
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| Summary: | Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune <em>dysregulation</em> leads to a <em>chronic low-grade inflammatory state</em> in aging. This is the basis of the new integrative theory called oxy-inflamm-aging. The present article describes the foundations of this theory, the current research studies that support it, and its link with the pathogenesis of some age-related diseases. It is concluded that the adoption of a healthy lifestyle from an early age can contribute to a successful aging. The benefits of caloric restriction and antioxidant supplements are still under study in order to prevent <em>oxidative stress </em>and <em>inflammation</em>, and consequently achieve greater longevity and reduce the burden of age-associated diseases. |
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| ISSN: | 1727-897X |