Combined Effects of Pericytes in the Tumor Microenvironment
Pericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of stem cells, contributing to the regeneration of d...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/868475 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553171265781760 |
|---|---|
| author | Aline Lopes Ribeiro Oswaldo Keith Okamoto |
| author_facet | Aline Lopes Ribeiro Oswaldo Keith Okamoto |
| author_sort | Aline Lopes Ribeiro |
| collection | DOAJ |
| description | Pericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of stem cells, contributing to the regeneration of diverse tissues. Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME). In this review, we highlight the contribution of pericytes to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss how collectively these hallmarks could be tackled by therapies targeting pericytes, providing a rationale for cancer drugs aiming at the TME. |
| format | Article |
| id | doaj-art-1449c495cd5e49e3a4f50142732f4c88 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1449c495cd5e49e3a4f50142732f4c882025-02-03T05:55:19ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/868475868475Combined Effects of Pericytes in the Tumor MicroenvironmentAline Lopes Ribeiro0Oswaldo Keith Okamoto1Centro de Pesquisa sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, Cidade Universitária, 05508-090 São Paulo, SP, BrazilCentro de Pesquisa sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, Cidade Universitária, 05508-090 São Paulo, SP, BrazilPericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of stem cells, contributing to the regeneration of diverse tissues. Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME). In this review, we highlight the contribution of pericytes to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss how collectively these hallmarks could be tackled by therapies targeting pericytes, providing a rationale for cancer drugs aiming at the TME.http://dx.doi.org/10.1155/2015/868475 |
| spellingShingle | Aline Lopes Ribeiro Oswaldo Keith Okamoto Combined Effects of Pericytes in the Tumor Microenvironment Stem Cells International |
| title | Combined Effects of Pericytes in the Tumor Microenvironment |
| title_full | Combined Effects of Pericytes in the Tumor Microenvironment |
| title_fullStr | Combined Effects of Pericytes in the Tumor Microenvironment |
| title_full_unstemmed | Combined Effects of Pericytes in the Tumor Microenvironment |
| title_short | Combined Effects of Pericytes in the Tumor Microenvironment |
| title_sort | combined effects of pericytes in the tumor microenvironment |
| url | http://dx.doi.org/10.1155/2015/868475 |
| work_keys_str_mv | AT alinelopesribeiro combinedeffectsofpericytesinthetumormicroenvironment AT oswaldokeithokamoto combinedeffectsofpericytesinthetumormicroenvironment |