A Novel Green Synthesis of Thalidomide and Analogs
Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation g...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/6436185 |
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| author | Ellis Benjamin Yousef M. Hijji |
| author_facet | Ellis Benjamin Yousef M. Hijji |
| author_sort | Ellis Benjamin |
| collection | DOAJ |
| description | Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields. |
| format | Article |
| id | doaj-art-143ed35f55254400a167bba909d38bd5 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-143ed35f55254400a167bba909d38bd52025-02-03T05:48:15ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/64361856436185A Novel Green Synthesis of Thalidomide and AnalogsEllis Benjamin0Yousef M. Hijji1Department of Chemistry, Stockton University, 101 Vera King Farris Drive, Galloway, NJ 08205-9441, USADepartment of Chemistry and Earth Sciences, Qatar University, P.O. Box 2713, Doha, QatarThalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.http://dx.doi.org/10.1155/2017/6436185 |
| spellingShingle | Ellis Benjamin Yousef M. Hijji A Novel Green Synthesis of Thalidomide and Analogs Journal of Chemistry |
| title | A Novel Green Synthesis of Thalidomide and Analogs |
| title_full | A Novel Green Synthesis of Thalidomide and Analogs |
| title_fullStr | A Novel Green Synthesis of Thalidomide and Analogs |
| title_full_unstemmed | A Novel Green Synthesis of Thalidomide and Analogs |
| title_short | A Novel Green Synthesis of Thalidomide and Analogs |
| title_sort | novel green synthesis of thalidomide and analogs |
| url | http://dx.doi.org/10.1155/2017/6436185 |
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