GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy
Our study aimed to assess the effects of Growth and differentiation factor 11 (GDF11) on the function of endothelial progenitor cells in middle-age individuals (EPCs-MA) isolated from mouse bone marrow and to explore the mechanistic relationship between GDF11 and age-related ALP impairment.
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-01-01
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| Series: | Frigid Zone Medicine |
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| Online Access: | https://doi.org/10.1515/fzm-2024-0021 |
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| _version_ | 1832570408302280704 |
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| author | Liu Donghua Zhang Yang Liu Xin Huang Qihe Zhang Xiaofang Yang Rui Zhao Yue Li Penghui He Jiayi Zhang Kexiao Pan Zhenwei Liu Huiwen Yang Baofeng |
| author_facet | Liu Donghua Zhang Yang Liu Xin Huang Qihe Zhang Xiaofang Yang Rui Zhao Yue Li Penghui He Jiayi Zhang Kexiao Pan Zhenwei Liu Huiwen Yang Baofeng |
| author_sort | Liu Donghua |
| collection | DOAJ |
| description | Our study aimed to assess the effects of Growth and differentiation factor 11 (GDF11) on the function of endothelial progenitor cells in middle-age individuals (EPCs-MA) isolated from mouse bone marrow and to explore the mechanistic relationship between GDF11 and age-related ALP impairment. |
| format | Article |
| id | doaj-art-142808021ed040d1b7e00fea675e05d1 |
| institution | Kabale University |
| issn | 2719-8073 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Frigid Zone Medicine |
| spelling | doaj-art-142808021ed040d1b7e00fea675e05d12025-02-02T15:45:29ZengDe GruyterFrigid Zone Medicine2719-80732025-01-014421222310.1515/fzm-2024-0021GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagyLiu Donghua0Zhang Yang1Liu Xin2Huang Qihe3Zhang Xiaofang4Yang Rui5Zhao Yue6Li Penghui7He Jiayi8Zhang Kexiao9Pan Zhenwei10Liu Huiwen11Yang Baofeng12Department of Histology and Embryology, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacy at the Second Affiliated Hospital, Harbin, 150086, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaDepartment of Histology and Embryology, Harbin Medical University, Harbin150081, ChinaDepartment of Histology and Embryology, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaDepartment of Histology and Embryology, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology, Harbin Medical University (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin150081, ChinaOur study aimed to assess the effects of Growth and differentiation factor 11 (GDF11) on the function of endothelial progenitor cells in middle-age individuals (EPCs-MA) isolated from mouse bone marrow and to explore the mechanistic relationship between GDF11 and age-related ALP impairment.https://doi.org/10.1515/fzm-2024-0021gdf11endothelial progenitor cellsautophagy lysosome pathwayaging |
| spellingShingle | Liu Donghua Zhang Yang Liu Xin Huang Qihe Zhang Xiaofang Yang Rui Zhao Yue Li Penghui He Jiayi Zhang Kexiao Pan Zhenwei Liu Huiwen Yang Baofeng GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy Frigid Zone Medicine gdf11 endothelial progenitor cells autophagy lysosome pathway aging |
| title | GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy |
| title_full | GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy |
| title_fullStr | GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy |
| title_full_unstemmed | GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy |
| title_short | GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy |
| title_sort | gdf11 restores the impaired function of epcs ma by promoting autophagy gdf11 ameliorates endothelial progenitor cell aging by promoting autophagy |
| topic | gdf11 endothelial progenitor cells autophagy lysosome pathway aging |
| url | https://doi.org/10.1515/fzm-2024-0021 |
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