Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature
Toxic epidermal necrolysis (TEN) is a rare immune-mediated adverse skin reaction; secondary in most cases to the administration of a drug. Due to its high mortality, immediate diagnosis and management in an intensive care unit is essential. In addition, temporary coverage of skin lesions should be p...
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Elsevier
2025-01-01
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| Series: | Burns Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468912224000749 |
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| author | Juan Ludeña Diana Rojas Pedro Ciudad Walter Navarro Rafael Rossi Annelisse Travi |
| author_facet | Juan Ludeña Diana Rojas Pedro Ciudad Walter Navarro Rafael Rossi Annelisse Travi |
| author_sort | Juan Ludeña |
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| description | Toxic epidermal necrolysis (TEN) is a rare immune-mediated adverse skin reaction; secondary in most cases to the administration of a drug. Due to its high mortality, immediate diagnosis and management in an intensive care unit is essential. In addition, temporary coverage of skin lesions should be performed to avoid fluid loss, reduce pain and prevent infection. An alternative for this is the use of porcine skin, which has been shown to have good aesthetic results in the management of TEN. Objective: To demonstrate the benefits provided by the use of porcine skin as a biological dressing in TEN injuries in the Plastic, Reconstructive and Burn Surgery service of the Arzobispo Loayza National Hospital. Method: Descriptive, retrospective study of TEN cases referred to our service from 2016 to 2020 where 9 patients were found, with dermal involvement >30 % of total body surface area (TBSA) and who underwent porcine skin as a biological dressing. Results: The most frequent identifiable cause of TEN was the use of antibiotics. The mortality was 33 %. Total epithelialization of the lesions was obtained in 7 of the 9 patients (77 %) and the mean epithelialization time was 14.2 days. Conclusion: The use of the porcine skin dressing is effective in patients with TEN and favors its re-epithelialization. |
| format | Article |
| id | doaj-art-1405cc4e8ab14832b7e5cc7f75803c83 |
| institution | Kabale University |
| issn | 2468-9122 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Burns Open |
| spelling | doaj-art-1405cc4e8ab14832b7e5cc7f75803c832025-01-19T06:26:26ZengElsevierBurns Open2468-91222025-01-019100386Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literatureJuan Ludeña0Diana Rojas1Pedro Ciudad2Walter Navarro3Rafael Rossi4Annelisse Travi5Department of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, Peru; Corresponding author.Department of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, PeruDepartment of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, PeruDepartment of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, PeruDepartment of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, PeruDepartment of Plastic and Burn Surgery, National Institute of Children’s Health, Lima, PeruToxic epidermal necrolysis (TEN) is a rare immune-mediated adverse skin reaction; secondary in most cases to the administration of a drug. Due to its high mortality, immediate diagnosis and management in an intensive care unit is essential. In addition, temporary coverage of skin lesions should be performed to avoid fluid loss, reduce pain and prevent infection. An alternative for this is the use of porcine skin, which has been shown to have good aesthetic results in the management of TEN. Objective: To demonstrate the benefits provided by the use of porcine skin as a biological dressing in TEN injuries in the Plastic, Reconstructive and Burn Surgery service of the Arzobispo Loayza National Hospital. Method: Descriptive, retrospective study of TEN cases referred to our service from 2016 to 2020 where 9 patients were found, with dermal involvement >30 % of total body surface area (TBSA) and who underwent porcine skin as a biological dressing. Results: The most frequent identifiable cause of TEN was the use of antibiotics. The mortality was 33 %. Total epithelialization of the lesions was obtained in 7 of the 9 patients (77 %) and the mean epithelialization time was 14.2 days. Conclusion: The use of the porcine skin dressing is effective in patients with TEN and favors its re-epithelialization.http://www.sciencedirect.com/science/article/pii/S2468912224000749TENEpithelializationPorcine skin |
| spellingShingle | Juan Ludeña Diana Rojas Pedro Ciudad Walter Navarro Rafael Rossi Annelisse Travi Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature Burns Open TEN Epithelialization Porcine skin |
| title | Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature |
| title_full | Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature |
| title_fullStr | Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature |
| title_full_unstemmed | Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature |
| title_short | Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature |
| title_sort | benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries review of the literature |
| topic | TEN Epithelialization Porcine skin |
| url | http://www.sciencedirect.com/science/article/pii/S2468912224000749 |
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