Mechanistic insights into the sleep-glymphopathy-cerebral small vessel disease loop: implications for epilepsy pathophysiology and therapy

Mechanistic insights into the sleep-glymphopathy-cerebral small vessel disease loop: implications for epilepsy pathophysiology and therapy

Epilepsy is the second most common neurological disorder and affects approximately 50 million people worldwide. Despite advances in antiepileptic therapy, about 30% of patients develop refractory epilepsy. Recent studies have shown sleep, glymphatic function, cerebral small vessel disease (CSVD), an...

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Bibliographic Details
Main Authors: Zaw Myo Hein, Zaid Adnan Subhi Al-Zaghal, Mazira Muhammad Ghazali, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Muhammad Danial Che Ramli, Che Mohd Nasril Che Mohd Nassir
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Neuroscience
Subjects:
sleep
glymphatic system
cerebral small vessel disease
epilepsy
therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1546482/full
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