Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research Hospital
Objective: This study retrospectively evaluates our laboratory Toxoplasma gondii immunoglobulin (Ig)M, IgG antibody and avidity test results to determine the distribution of the pathogen according to sex, age, clinics and years. Methods: The serum samples sent to Pamukkale University Healthcare Res...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2024-12-01
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| Series: | Türkiye Parazitoloji Dergisi |
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| Online Access: | https://www.turkiyeparazitolderg.org/articles/retrospective-evaluation-of-lessemgreatertoxoplasma-gondii-lessemgreatertest-results-in-patients-applying-to-a-research-hospital/doi/tpd.galenos.2025.44227 |
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| author | Sedef Zeliha Öner İlknur Kaleli Melek Demir Ahmet Çalışkan Ergun Mete Hande Şenol Çağrı Ergin |
| author_facet | Sedef Zeliha Öner İlknur Kaleli Melek Demir Ahmet Çalışkan Ergun Mete Hande Şenol Çağrı Ergin |
| author_sort | Sedef Zeliha Öner |
| collection | DOAJ |
| description | Objective: This study retrospectively evaluates our laboratory Toxoplasma gondii immunoglobulin (Ig)M, IgG antibody and avidity test results to determine the distribution of the pathogen according to sex, age, clinics and years.
Methods: The serum samples sent to Pamukkale University Healthcare Research and Practice Hospital’s Medical Microbiology laboratory between January 2016 and December 2023 were evaluated for T. gondii seropositivity. Toxoplasma antibodies and avidity testing were studied using chemiluminescent microparticle immunological testing method (Abbott Architect i2000SR, Weisbaden, Germany).
Results: The study evaluated 42,817 tests ordered from patients with suspected toxoplasmosis. Five hundred-three (2.1%) were found to be anti-T. gondii-IgM positive and 4.406 (24.7%) to be anti-T. gondii-IgG positive. Anti-T. gondii-IgM and anti-T. gondii-IgG positivity were significantly higher in women than in men (p=0.0001; p=0.0001, respectively). Anti-T. gondii-IgM positivity was found to be high between the ages of 19 and 49 (p=0.0001). The anti-T. gondii-IgG positivity rate increased with age (p=0.0001). Anti-T. gondii-IgM and anti-T. gondii-IgG positivity rates have decreased significantly over the last four years (2020-2023) compared to the first four years (2016-2019) (p=0.0001; p=0.0001, respectively). When the results of 582 patients with T. gondii-avidity requests were evaluated, 38.1% of the anti-T. gondii-IgM positive patients and 7.8% of the anti-T. gondii-IgM negative patients had low avidity.
Conclusion: T. gondii seroprevalence was found to be similar to the global average, with female sex, age and nationality among the risk factors. It has also been observed that seroprevalence has significantly decreased in recent years. |
| format | Article |
| id | doaj-art-13fbad1d335e43da99d461a3a8f168bd |
| institution | Kabale University |
| issn | 1300-6320 2146-3077 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türkiye Parazitoloji Dergisi |
| spelling | doaj-art-13fbad1d335e43da99d461a3a8f168bd2025-01-23T07:56:03ZengGalenos YayineviTürkiye Parazitoloji Dergisi1300-63202146-30772024-12-0148424525010.4274/tpd.galenos.2025.44227Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research HospitalSedef Zeliha Öner0https://orcid.org/0000-0002-9964-2526İlknur Kaleli1https://orcid.org/0000-0001-9689-8297Melek Demir2https://orcid.org/0000-0002-1551-9265Ahmet Çalışkan3https://orcid.org/0000-0002-1156-3787Ergun Mete4https://orcid.org/0000-0002-0854-2440Hande Şenol5https://orcid.org/0000-0001-6395-7924Çağrı Ergin6https://orcid.org/0000-0001-7783-8723Pamukkale University Faculty of Medicine, Department of Medical Microbiology, Denizli, TürkiyePamukkale University Faculty of Medicine, Department of Medical Microbiology, Denizli, TürkiyePamukkale University Faculty of Medicine, Department of Medical Microbiology, Denizli, TürkiyePamukkale University Faculty of Medicine, Department of Medical Microbiology, Denizli, TürkiyePamukkale University Faculty of Medicine, Department of Medical Microbiology, Denizli, TürkiyePamukkale University Faculty of Medicine, Department of Biostatistics, Denizli, TürkiyePamukkale University Faculty of Medicine, Department of Medical Microbiology, Denizli, TürkiyeObjective: This study retrospectively evaluates our laboratory Toxoplasma gondii immunoglobulin (Ig)M, IgG antibody and avidity test results to determine the distribution of the pathogen according to sex, age, clinics and years. Methods: The serum samples sent to Pamukkale University Healthcare Research and Practice Hospital’s Medical Microbiology laboratory between January 2016 and December 2023 were evaluated for T. gondii seropositivity. Toxoplasma antibodies and avidity testing were studied using chemiluminescent microparticle immunological testing method (Abbott Architect i2000SR, Weisbaden, Germany). Results: The study evaluated 42,817 tests ordered from patients with suspected toxoplasmosis. Five hundred-three (2.1%) were found to be anti-T. gondii-IgM positive and 4.406 (24.7%) to be anti-T. gondii-IgG positive. Anti-T. gondii-IgM and anti-T. gondii-IgG positivity were significantly higher in women than in men (p=0.0001; p=0.0001, respectively). Anti-T. gondii-IgM positivity was found to be high between the ages of 19 and 49 (p=0.0001). The anti-T. gondii-IgG positivity rate increased with age (p=0.0001). Anti-T. gondii-IgM and anti-T. gondii-IgG positivity rates have decreased significantly over the last four years (2020-2023) compared to the first four years (2016-2019) (p=0.0001; p=0.0001, respectively). When the results of 582 patients with T. gondii-avidity requests were evaluated, 38.1% of the anti-T. gondii-IgM positive patients and 7.8% of the anti-T. gondii-IgM negative patients had low avidity. Conclusion: T. gondii seroprevalence was found to be similar to the global average, with female sex, age and nationality among the risk factors. It has also been observed that seroprevalence has significantly decreased in recent years.https://www.turkiyeparazitolderg.org/articles/retrospective-evaluation-of-lessemgreatertoxoplasma-gondii-lessemgreatertest-results-in-patients-applying-to-a-research-hospital/doi/tpd.galenos.2025.44227toxoplasma gondiiseroprevalenceagechange over years |
| spellingShingle | Sedef Zeliha Öner İlknur Kaleli Melek Demir Ahmet Çalışkan Ergun Mete Hande Şenol Çağrı Ergin Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research Hospital Türkiye Parazitoloji Dergisi toxoplasma gondii seroprevalence age change over years |
| title | Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research Hospital |
| title_full | Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research Hospital |
| title_fullStr | Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research Hospital |
| title_full_unstemmed | Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research Hospital |
| title_short | Retrospective Evaluation of Toxoplasma gondii Test Results in Patients Applying to A Research Hospital |
| title_sort | retrospective evaluation of toxoplasma gondii test results in patients applying to a research hospital |
| topic | toxoplasma gondii seroprevalence age change over years |
| url | https://www.turkiyeparazitolderg.org/articles/retrospective-evaluation-of-lessemgreatertoxoplasma-gondii-lessemgreatertest-results-in-patients-applying-to-a-research-hospital/doi/tpd.galenos.2025.44227 |
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