Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
Introduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Meth...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2014/876521 |
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| author | Amedeo Minichino Francesco Saverio Bersani Francesco Spagnoli Alessandra Corrado Francesco De Michele Wanda Katharina Calò Martina Primavera Baoran Yang Laura Bernabei Francesco Macrì Lucilla Vergnani Massimo Biondi Roberto Delle Chiaie |
| author_facet | Amedeo Minichino Francesco Saverio Bersani Francesco Spagnoli Alessandra Corrado Francesco De Michele Wanda Katharina Calò Martina Primavera Baoran Yang Laura Bernabei Francesco Macrì Lucilla Vergnani Massimo Biondi Roberto Delle Chiaie |
| author_sort | Amedeo Minichino |
| collection | DOAJ |
| description | Introduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Methods. 25 euthymic outpatients with a diagnosis of BD Type I or II have been enrolled in the study. tDCS montage was as follows: cathode on the right cerebellar cortex and anode over the left dorsolateral prefrontal cortex (DLPFC); the intensity of stimulation was set at 2 mA and delivered for 20 min/die for 3 consecutive weeks. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at baseline and after the tDCS treatment. Results. PSQI total score and all PSQI subdomains, with the exception of “sleep medication,” significantly improved after treatment. Discussion. This is the first study where a positive effect of tDCS on the quality of sleep in euthymic BD patients has been reported. As both prefrontal cortex and cerebellum may play a role in regulating sleep processes, concomitant cathodal (inhibitory) stimulation of cerebellum and anodal (excitatory) stimulation of DLPFC may have the potential to modulate prefrontal-thalamic-cerebellar circuits leading to improvements of sleep quality. |
| format | Article |
| id | doaj-art-13f2a627e72846c3b87c74f0c4bfa3a7 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-13f2a627e72846c3b87c74f0c4bfa3a72025-02-03T05:52:51ZengWileyBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/876521876521Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief ReportAmedeo Minichino0Francesco Saverio Bersani1Francesco Spagnoli2Alessandra Corrado3Francesco De Michele4Wanda Katharina Calò5Martina Primavera6Baoran Yang7Laura Bernabei8Francesco Macrì9Lucilla Vergnani10Massimo Biondi11Roberto Delle Chiaie12Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyIntroduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Methods. 25 euthymic outpatients with a diagnosis of BD Type I or II have been enrolled in the study. tDCS montage was as follows: cathode on the right cerebellar cortex and anode over the left dorsolateral prefrontal cortex (DLPFC); the intensity of stimulation was set at 2 mA and delivered for 20 min/die for 3 consecutive weeks. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at baseline and after the tDCS treatment. Results. PSQI total score and all PSQI subdomains, with the exception of “sleep medication,” significantly improved after treatment. Discussion. This is the first study where a positive effect of tDCS on the quality of sleep in euthymic BD patients has been reported. As both prefrontal cortex and cerebellum may play a role in regulating sleep processes, concomitant cathodal (inhibitory) stimulation of cerebellum and anodal (excitatory) stimulation of DLPFC may have the potential to modulate prefrontal-thalamic-cerebellar circuits leading to improvements of sleep quality.http://dx.doi.org/10.1155/2014/876521 |
| spellingShingle | Amedeo Minichino Francesco Saverio Bersani Francesco Spagnoli Alessandra Corrado Francesco De Michele Wanda Katharina Calò Martina Primavera Baoran Yang Laura Bernabei Francesco Macrì Lucilla Vergnani Massimo Biondi Roberto Delle Chiaie Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report Behavioural Neurology |
| title | Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report |
| title_full | Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report |
| title_fullStr | Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report |
| title_full_unstemmed | Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report |
| title_short | Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report |
| title_sort | prefronto cerebellar transcranial direct current stimulation improves sleep quality in euthymic bipolar patients a brief report |
| url | http://dx.doi.org/10.1155/2014/876521 |
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