Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report

Introduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Meth...

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Main Authors: Amedeo Minichino, Francesco Saverio Bersani, Francesco Spagnoli, Alessandra Corrado, Francesco De Michele, Wanda Katharina Calò, Martina Primavera, Baoran Yang, Laura Bernabei, Francesco Macrì, Lucilla Vergnani, Massimo Biondi, Roberto Delle Chiaie
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.1155/2014/876521
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author Amedeo Minichino
Francesco Saverio Bersani
Francesco Spagnoli
Alessandra Corrado
Francesco De Michele
Wanda Katharina Calò
Martina Primavera
Baoran Yang
Laura Bernabei
Francesco Macrì
Lucilla Vergnani
Massimo Biondi
Roberto Delle Chiaie
author_facet Amedeo Minichino
Francesco Saverio Bersani
Francesco Spagnoli
Alessandra Corrado
Francesco De Michele
Wanda Katharina Calò
Martina Primavera
Baoran Yang
Laura Bernabei
Francesco Macrì
Lucilla Vergnani
Massimo Biondi
Roberto Delle Chiaie
author_sort Amedeo Minichino
collection DOAJ
description Introduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Methods. 25 euthymic outpatients with a diagnosis of BD Type I or II have been enrolled in the study. tDCS montage was as follows: cathode on the right cerebellar cortex and anode over the left dorsolateral prefrontal cortex (DLPFC); the intensity of stimulation was set at 2 mA and delivered for 20 min/die for 3 consecutive weeks. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at baseline and after the tDCS treatment. Results. PSQI total score and all PSQI subdomains, with the exception of “sleep medication,” significantly improved after treatment. Discussion. This is the first study where a positive effect of tDCS on the quality of sleep in euthymic BD patients has been reported. As both prefrontal cortex and cerebellum may play a role in regulating sleep processes, concomitant cathodal (inhibitory) stimulation of cerebellum and anodal (excitatory) stimulation of DLPFC may have the potential to modulate prefrontal-thalamic-cerebellar circuits leading to improvements of sleep quality.
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spelling doaj-art-13f2a627e72846c3b87c74f0c4bfa3a72025-02-03T05:52:51ZengWileyBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/876521876521Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief ReportAmedeo Minichino0Francesco Saverio Bersani1Francesco Spagnoli2Alessandra Corrado3Francesco De Michele4Wanda Katharina Calò5Martina Primavera6Baoran Yang7Laura Bernabei8Francesco Macrì9Lucilla Vergnani10Massimo Biondi11Roberto Delle Chiaie12Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Università 30, 00185 Rome, ItalyIntroduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Methods. 25 euthymic outpatients with a diagnosis of BD Type I or II have been enrolled in the study. tDCS montage was as follows: cathode on the right cerebellar cortex and anode over the left dorsolateral prefrontal cortex (DLPFC); the intensity of stimulation was set at 2 mA and delivered for 20 min/die for 3 consecutive weeks. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at baseline and after the tDCS treatment. Results. PSQI total score and all PSQI subdomains, with the exception of “sleep medication,” significantly improved after treatment. Discussion. This is the first study where a positive effect of tDCS on the quality of sleep in euthymic BD patients has been reported. As both prefrontal cortex and cerebellum may play a role in regulating sleep processes, concomitant cathodal (inhibitory) stimulation of cerebellum and anodal (excitatory) stimulation of DLPFC may have the potential to modulate prefrontal-thalamic-cerebellar circuits leading to improvements of sleep quality.http://dx.doi.org/10.1155/2014/876521
spellingShingle Amedeo Minichino
Francesco Saverio Bersani
Francesco Spagnoli
Alessandra Corrado
Francesco De Michele
Wanda Katharina Calò
Martina Primavera
Baoran Yang
Laura Bernabei
Francesco Macrì
Lucilla Vergnani
Massimo Biondi
Roberto Delle Chiaie
Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
Behavioural Neurology
title Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_full Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_fullStr Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_full_unstemmed Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_short Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_sort prefronto cerebellar transcranial direct current stimulation improves sleep quality in euthymic bipolar patients a brief report
url http://dx.doi.org/10.1155/2014/876521
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