Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma
Altered natural killer (NK) cell function is a component of the global immune dysregulation that occurs in advanced malignancies. Another condition associated with altered NK homeostasis is normal pregnancy, where robust infiltration with CD16− CD9+ NK cells can be identified in decidual tissues, al...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/316314 |
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| author | Shernan G. Holtan Douglas J. Creedon Michael A. Thompson Wendy K. Nevala Svetomir N. Markovic |
| author_facet | Shernan G. Holtan Douglas J. Creedon Michael A. Thompson Wendy K. Nevala Svetomir N. Markovic |
| author_sort | Shernan G. Holtan |
| collection | DOAJ |
| description | Altered natural killer (NK) cell function is a component of the global immune dysregulation that occurs in advanced malignancies. Another condition associated with altered NK homeostasis is normal pregnancy, where robust infiltration with CD16− CD9+ NK cells can be identified in decidual tissues, along with a concomitant expansion of CD16− NK cells in the maternal peripheral blood. In metastatic melanoma, we identified a similar expansion of peripheral blood CD16− NK cells (median 7.4% in 41 patients with melanoma compared with 3.0% in 29 controls, P<.001). A subset of NK cells in melanoma patients also expresses CD9, which is characteristically expressed only on NK cells within the female reproductive tract. Expansion of CD16− NK cells was associated with elevated plasma transforming growth factor-beta (TGF-β levels (median 20 ng/ml, Spearman's ρ=0.81,P=.015)). These findings suggest the possibility of exploring anti-TGF-β therapy to restore NK function in melanoma. |
| format | Article |
| id | doaj-art-13e9ff5a03e648a4a14a3d06c226a521 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-13e9ff5a03e648a4a14a3d06c226a5212025-02-03T01:22:19ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/316314316314Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic MelanomaShernan G. Holtan0Douglas J. Creedon1Michael A. Thompson2Wendy K. Nevala3Svetomir N. Markovic4Division of Hematology, Department of Medicine, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Obstetrics and Gynecology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Immunology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Immunology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USADivision of Hematology, Department of Medicine, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USAAltered natural killer (NK) cell function is a component of the global immune dysregulation that occurs in advanced malignancies. Another condition associated with altered NK homeostasis is normal pregnancy, where robust infiltration with CD16− CD9+ NK cells can be identified in decidual tissues, along with a concomitant expansion of CD16− NK cells in the maternal peripheral blood. In metastatic melanoma, we identified a similar expansion of peripheral blood CD16− NK cells (median 7.4% in 41 patients with melanoma compared with 3.0% in 29 controls, P<.001). A subset of NK cells in melanoma patients also expresses CD9, which is characteristically expressed only on NK cells within the female reproductive tract. Expansion of CD16− NK cells was associated with elevated plasma transforming growth factor-beta (TGF-β levels (median 20 ng/ml, Spearman's ρ=0.81,P=.015)). These findings suggest the possibility of exploring anti-TGF-β therapy to restore NK function in melanoma.http://dx.doi.org/10.1155/2011/316314 |
| spellingShingle | Shernan G. Holtan Douglas J. Creedon Michael A. Thompson Wendy K. Nevala Svetomir N. Markovic Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma Clinical and Developmental Immunology |
| title | Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma |
| title_full | Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma |
| title_fullStr | Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma |
| title_full_unstemmed | Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma |
| title_short | Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma |
| title_sort | expansion of cd16 negative natural killer cells in the peripheral blood of patients with metastatic melanoma |
| url | http://dx.doi.org/10.1155/2011/316314 |
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