A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is one of the most common complications in patients with Acquired Immune Deficiency Syndrome (AIDS), yet its prognosis is generally poor. The impact of surgery on DLBCL remains controversial. We present a case of DLBCL associated with HIV inf...
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BMC
2024-11-01
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| Series: | Diagnostic Pathology |
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| Online Access: | https://doi.org/10.1186/s13000-024-01562-6 |
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| author | Qiaoqiao Zhang Jingzhen Lai Sufang Ai Shulin Song Junjun Jiang Zhiman Xie |
| author_facet | Qiaoqiao Zhang Jingzhen Lai Sufang Ai Shulin Song Junjun Jiang Zhiman Xie |
| author_sort | Qiaoqiao Zhang |
| collection | DOAJ |
| description | Abstract Background Diffuse large B-cell lymphoma (DLBCL) is one of the most common complications in patients with Acquired Immune Deficiency Syndrome (AIDS), yet its prognosis is generally poor. The impact of surgery on DLBCL remains controversial. We present a case of DLBCL associated with HIV infection, in which the patient achieved complete remission following surgical removal, radiotherapy, and sequential dose-adjusted EPOCH (DA-EPOCH) chemotherapy. Case summary A thirty-year-old man presented with dizziness and headache on September 24, 2019. He had a history of AIDS and pulmonary tuberculosis. He was initially diagnosed with left cerebellar astrocytoma and chronic pneumonia at a local hospital. At our hospital, following magnetic resonance imaging (MRI) and surgical intervention, pathology and immunohistochemistry results indicated DLBCL in the left cerebellar hemisphere. He subsequently underwent resection of the tumor in the left cerebellar hemisphere, received radiotherapy for half a month, and completed sequential DA-EPOCH chemotherapy for seven cycles. His symptoms improved, and the prognosis was favorable, with no signs of recurrence after 4 years of follow-up. Conclusion Surgery is applicable to isolated and superficial lesions. However, it should be combined with radiotherapy and chemotherapy to achieve better treatment. |
| format | Article |
| id | doaj-art-13dfd721fb3c4d5fb691fb9fb4bf8d7f |
| institution | OA Journals |
| issn | 1746-1596 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj-art-13dfd721fb3c4d5fb691fb9fb4bf8d7f2025-08-20T02:08:20ZengBMCDiagnostic Pathology1746-15962024-11-011911710.1186/s13000-024-01562-6A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infectionQiaoqiao Zhang0Jingzhen Lai1Sufang Ai2Shulin Song3Junjun Jiang4Zhiman Xie5Department of Infectious Diseases, The Fourth People’s Hospital of NanningGuangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical UniversityDepartment of Infectious Diseases, The Fourth People’s Hospital of NanningDepartment of Radiology, The Fourth People’s Hospital of NanningGuangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical UniversityDepartment of Infectious Diseases, The Fourth People’s Hospital of NanningAbstract Background Diffuse large B-cell lymphoma (DLBCL) is one of the most common complications in patients with Acquired Immune Deficiency Syndrome (AIDS), yet its prognosis is generally poor. The impact of surgery on DLBCL remains controversial. We present a case of DLBCL associated with HIV infection, in which the patient achieved complete remission following surgical removal, radiotherapy, and sequential dose-adjusted EPOCH (DA-EPOCH) chemotherapy. Case summary A thirty-year-old man presented with dizziness and headache on September 24, 2019. He had a history of AIDS and pulmonary tuberculosis. He was initially diagnosed with left cerebellar astrocytoma and chronic pneumonia at a local hospital. At our hospital, following magnetic resonance imaging (MRI) and surgical intervention, pathology and immunohistochemistry results indicated DLBCL in the left cerebellar hemisphere. He subsequently underwent resection of the tumor in the left cerebellar hemisphere, received radiotherapy for half a month, and completed sequential DA-EPOCH chemotherapy for seven cycles. His symptoms improved, and the prognosis was favorable, with no signs of recurrence after 4 years of follow-up. Conclusion Surgery is applicable to isolated and superficial lesions. However, it should be combined with radiotherapy and chemotherapy to achieve better treatment.https://doi.org/10.1186/s13000-024-01562-6DLBCLPCNSLHIVSurgeryDA-EPOCH |
| spellingShingle | Qiaoqiao Zhang Jingzhen Lai Sufang Ai Shulin Song Junjun Jiang Zhiman Xie A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection Diagnostic Pathology DLBCL PCNSL HIV Surgery DA-EPOCH |
| title | A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection |
| title_full | A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection |
| title_fullStr | A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection |
| title_full_unstemmed | A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection |
| title_short | A case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection |
| title_sort | case report of surgery radiotherapy chemotherapy cured primary diffuse large b cell lymphoma of the central nervous system associated with hiv infection |
| topic | DLBCL PCNSL HIV Surgery DA-EPOCH |
| url | https://doi.org/10.1186/s13000-024-01562-6 |
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