Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface?
Flavonoids can exert beneficial health effects through multiple mechanisms. In this paper, we address the important, although not fully understood, capacity of flavonoids to interact with cell membranes. The interactions of polyphenols with bilayers include: (a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/10446670410001722168 |
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| _version_ | 1832555971908468736 |
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| author | Patricia I. Oteiza Alejandra G. Erlejman Sandra V. Verstraeten Carl L. Keen César G. Fraga |
| author_facet | Patricia I. Oteiza Alejandra G. Erlejman Sandra V. Verstraeten Carl L. Keen César G. Fraga |
| author_sort | Patricia I. Oteiza |
| collection | DOAJ |
| description | Flavonoids can exert beneficial health effects through multiple mechanisms. In
this paper, we address the important, although not fully understood, capacity of
flavonoids to interact with cell membranes. The interactions of polyphenols with
bilayers include: (a) the partition of the more non-polar compounds in the
hydrophobic interior of the membrane, and (b) the formation of hydrogen bonds
between the polar head groups of lipids and the more hydrophilic flavonoids at the
membrane interface. The consequences of these interactions are discussed. The
induction of changes in membrane physical properties can affect the rates of
membrane lipid and protein oxidation. The partition of certain flavonoids in the
hydrophobic core can result in a chain breaking antioxidant activity. We suggest
that interactions of polyphenols at the surface of bilayers through hydrogen
bonding, can act to reduce the access of deleterious
molecules (i.e. oxidants), thus protecting the structure and function of membranes. |
| format | Article |
| id | doaj-art-13d72264a63148929d0495d5dda8ff80 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-13d72264a63148929d0495d5dda8ff802025-02-03T05:46:36ZengWileyClinical and Developmental Immunology1740-25221740-25302005-01-01121192510.1080/10446670410001722168Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface?Patricia I. Oteiza0Alejandra G. Erlejman1Sandra V. Verstraeten2Carl L. Keen3César G. Fraga4Department of Biological Chemistry, IQUIFIB (UBA-CONICET), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, ArgentinaDepartment of Biological Chemistry, IQUIFIB (UBA-CONICET), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, ArgentinaDepartment of Biological Chemistry, IQUIFIB (UBA-CONICET), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, ArgentinaDepartment of Nutrition, University of California, Davis, CA, USADepartment of Biological Chemistry, IQUIFIB (UBA-CONICET), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, ArgentinaFlavonoids can exert beneficial health effects through multiple mechanisms. In this paper, we address the important, although not fully understood, capacity of flavonoids to interact with cell membranes. The interactions of polyphenols with bilayers include: (a) the partition of the more non-polar compounds in the hydrophobic interior of the membrane, and (b) the formation of hydrogen bonds between the polar head groups of lipids and the more hydrophilic flavonoids at the membrane interface. The consequences of these interactions are discussed. The induction of changes in membrane physical properties can affect the rates of membrane lipid and protein oxidation. The partition of certain flavonoids in the hydrophobic core can result in a chain breaking antioxidant activity. We suggest that interactions of polyphenols at the surface of bilayers through hydrogen bonding, can act to reduce the access of deleterious molecules (i.e. oxidants), thus protecting the structure and function of membranes.http://dx.doi.org/10.1080/10446670410001722168 |
| spellingShingle | Patricia I. Oteiza Alejandra G. Erlejman Sandra V. Verstraeten Carl L. Keen César G. Fraga Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface? Clinical and Developmental Immunology |
| title | Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface? |
| title_full | Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface? |
| title_fullStr | Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface? |
| title_full_unstemmed | Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface? |
| title_short | Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface? |
| title_sort | flavonoid membrane interactions a protective role of flavonoids at the membrane surface |
| url | http://dx.doi.org/10.1080/10446670410001722168 |
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