Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments
AimsThe study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.MethodsPotatoes are utilized as a display of the irreversible electroporation les...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1525762/full |
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| author | Yunhao Li Yunhao Li Fengqi Xuan Daoyang Zhang Daoyang Zhang Mingyu Sun Mingyu Sun Ping Zhang Qi Zhang Jie Zhang Yaling Han Yaling Han Zulu Wang Ming Liang Ming Liang |
| author_facet | Yunhao Li Yunhao Li Fengqi Xuan Daoyang Zhang Daoyang Zhang Mingyu Sun Mingyu Sun Ping Zhang Qi Zhang Jie Zhang Yaling Han Yaling Han Zulu Wang Ming Liang Ming Liang |
| author_sort | Yunhao Li |
| collection | DOAJ |
| description | AimsThe study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.MethodsPotatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.Results and conclusionThe key ablation parameters have varying degrees of influence on lesion depths, following the order of PW>V; V>P; PW>P; N>P. Lesion depths increased with higher values of V and P. However, when the total number of pulses reached 9,600, there was no significant increase in injury depth. |
| format | Article |
| id | doaj-art-13cfa834505043f9a3aa7c358e9f135b |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-13cfa834505043f9a3aa7c358e9f135b2025-02-04T06:32:02ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.15257621525762Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experimentsYunhao Li0Yunhao Li1Fengqi Xuan2Daoyang Zhang3Daoyang Zhang4Mingyu Sun5Mingyu Sun6Ping Zhang7Qi Zhang8Jie Zhang9Yaling Han10Yaling Han11Zulu Wang12Ming Liang13Ming Liang14Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaGraduate School of China Medical University, China Medical University, Shenyang, ChinaDepartment of Cardiology, Tianjin Chest Hospital, Tianjin, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaGraduate School of Dalian Medical University, Dalian Medical University, Dalian, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaNational Key Laboratory of Frigid Zone Cardiovascular Diseases, Shenyang, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaNational Key Laboratory of Frigid Zone Cardiovascular Diseases, Shenyang, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaNational Key Laboratory of Frigid Zone Cardiovascular Diseases, Shenyang, ChinaAimsThe study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.MethodsPotatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.Results and conclusionThe key ablation parameters have varying degrees of influence on lesion depths, following the order of PW>V; V>P; PW>P; N>P. Lesion depths increased with higher values of V and P. However, when the total number of pulses reached 9,600, there was no significant increase in injury depth.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1525762/fullpulsed field ablationkey parameterspre-clinical studypulmonary vein isolationtomato |
| spellingShingle | Yunhao Li Yunhao Li Fengqi Xuan Daoyang Zhang Daoyang Zhang Mingyu Sun Mingyu Sun Ping Zhang Qi Zhang Jie Zhang Yaling Han Yaling Han Zulu Wang Ming Liang Ming Liang Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments Frontiers in Cardiovascular Medicine pulsed field ablation key parameters pre-clinical study pulmonary vein isolation tomato |
| title | Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments |
| title_full | Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments |
| title_fullStr | Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments |
| title_full_unstemmed | Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments |
| title_short | Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments |
| title_sort | effects of key parameters on pulsed field ablation of atrial fibrillation potato experiments |
| topic | pulsed field ablation key parameters pre-clinical study pulmonary vein isolation tomato |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1525762/full |
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