Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments

Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments

AimsThe study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.MethodsPotatoes are utilized as a display of the irreversible electroporation les...

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Bibliographic Details
Main Authors: Yunhao Li, Fengqi Xuan, Daoyang Zhang, Mingyu Sun, Ping Zhang, Qi Zhang, Jie Zhang, Yaling Han, Zulu Wang, Ming Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
pulsed field ablation
key parameters
pre-clinical study
pulmonary vein isolation
tomato
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1525762/full
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Summary:AimsThe study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.MethodsPotatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.Results and conclusionThe key ablation parameters have varying degrees of influence on lesion depths, following the order of PW>V; V>P; PW>P; N>P. Lesion depths increased with higher values of V and P. However, when the total number of pulses reached 9,600, there was no significant increase in injury depth.
ISSN:2297-055X

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