Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pr...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/291375 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559743911067648 |
|---|---|
| author | Joseph H. Sisson Todd A. Wyatt Jacqueline A. Pavlik Pawanjit S. Sarna Peter J. Murphy |
| author_facet | Joseph H. Sisson Todd A. Wyatt Jacqueline A. Pavlik Pawanjit S. Sarna Peter J. Murphy |
| author_sort | Joseph H. Sisson |
| collection | DOAJ |
| description | Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; ). CF subjects had a trend toward lower EBC . Conclusion. We found an association between VCPT-stimulated clearance and exhaled levels in human subjects. We speculate that VCPT stimulates clearance via increased NO metabolism. |
| format | Article |
| id | doaj-art-13c9cbfa52b14661acc8b787e34de750 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-13c9cbfa52b14661acc8b787e34de7502025-02-03T01:29:16ZengWileyPulmonary Medicine2090-18362090-18442013-01-01201310.1155/2013/291375291375Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide MetabolismJoseph H. Sisson0Todd A. Wyatt1Jacqueline A. Pavlik2Pawanjit S. Sarna3Peter J. Murphy4Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USAPulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USAPulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USAPulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USAPulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USABackground. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; ). CF subjects had a trend toward lower EBC . Conclusion. We found an association between VCPT-stimulated clearance and exhaled levels in human subjects. We speculate that VCPT stimulates clearance via increased NO metabolism.http://dx.doi.org/10.1155/2013/291375 |
| spellingShingle | Joseph H. Sisson Todd A. Wyatt Jacqueline A. Pavlik Pawanjit S. Sarna Peter J. Murphy Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism Pulmonary Medicine |
| title | Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism |
| title_full | Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism |
| title_fullStr | Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism |
| title_full_unstemmed | Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism |
| title_short | Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism |
| title_sort | vest chest physiotherapy airway clearance is associated with nitric oxide metabolism |
| url | http://dx.doi.org/10.1155/2013/291375 |
| work_keys_str_mv | AT josephhsisson vestchestphysiotherapyairwayclearanceisassociatedwithnitricoxidemetabolism AT toddawyatt vestchestphysiotherapyairwayclearanceisassociatedwithnitricoxidemetabolism AT jacquelineapavlik vestchestphysiotherapyairwayclearanceisassociatedwithnitricoxidemetabolism AT pawanjitssarna vestchestphysiotherapyairwayclearanceisassociatedwithnitricoxidemetabolism AT peterjmurphy vestchestphysiotherapyairwayclearanceisassociatedwithnitricoxidemetabolism |