TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms
Tumor necrosis factor (TNF) tolerance in monocytes and macrophages means that preexposure to TNF reduces the sensitivity in these cells to a subsequent restimulation with this cytokine. Differential effects arise following preincubation with both low and high doses of TNF resulting in absolute as we...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9570129 |
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| _version_ | 1832549073642586112 |
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| author | René Huber Rolf Bikker Bastian Welz Martin Christmann Korbinian Brand |
| author_facet | René Huber Rolf Bikker Bastian Welz Martin Christmann Korbinian Brand |
| author_sort | René Huber |
| collection | DOAJ |
| description | Tumor necrosis factor (TNF) tolerance in monocytes and macrophages means that preexposure to TNF reduces the sensitivity in these cells to a subsequent restimulation with this cytokine. Differential effects arise following preincubation with both low and high doses of TNF resulting in absolute as well as induction tolerance affecting specific immunologically relevant gene sets. In this review article, we summarize the relevance of TNF tolerance in vivo and the molecular mechanisms underlying these forms of tolerance including the role of transcription factors and signaling systems. In addition, the characteristics of cross-tolerance between TNF and lipopolysaccharide (LPS) as well as pathophysiological aspects of TNF tolerance are discussed. We conclude that TNF tolerance may represent a protective mechanism involved in the termination of inflammation and preventing excessive or prolonged inflammation. Otherwise, tolerance may also be a trigger of immune paralysis thus contributing to severe inflammatory diseases such as sepsis. An improved understanding of TNF tolerance will presumably facilitate the implementation of diagnostic or therapeutic approaches to more precisely assess and treat inflammation-related diseases. |
| format | Article |
| id | doaj-art-13c41bfbf57c4f81a92a2e496d56237b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-13c41bfbf57c4f81a92a2e496d56237b2025-02-03T06:12:11ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/95701299570129TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular MechanismsRené Huber0Rolf Bikker1Bastian Welz2Martin Christmann3Korbinian Brand4Institute of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyInstitute of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyInstitute of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyInstitute of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyInstitute of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyTumor necrosis factor (TNF) tolerance in monocytes and macrophages means that preexposure to TNF reduces the sensitivity in these cells to a subsequent restimulation with this cytokine. Differential effects arise following preincubation with both low and high doses of TNF resulting in absolute as well as induction tolerance affecting specific immunologically relevant gene sets. In this review article, we summarize the relevance of TNF tolerance in vivo and the molecular mechanisms underlying these forms of tolerance including the role of transcription factors and signaling systems. In addition, the characteristics of cross-tolerance between TNF and lipopolysaccharide (LPS) as well as pathophysiological aspects of TNF tolerance are discussed. We conclude that TNF tolerance may represent a protective mechanism involved in the termination of inflammation and preventing excessive or prolonged inflammation. Otherwise, tolerance may also be a trigger of immune paralysis thus contributing to severe inflammatory diseases such as sepsis. An improved understanding of TNF tolerance will presumably facilitate the implementation of diagnostic or therapeutic approaches to more precisely assess and treat inflammation-related diseases.http://dx.doi.org/10.1155/2017/9570129 |
| spellingShingle | René Huber Rolf Bikker Bastian Welz Martin Christmann Korbinian Brand TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms Journal of Immunology Research |
| title | TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms |
| title_full | TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms |
| title_fullStr | TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms |
| title_full_unstemmed | TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms |
| title_short | TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms |
| title_sort | tnf tolerance in monocytes and macrophages characteristics and molecular mechanisms |
| url | http://dx.doi.org/10.1155/2017/9570129 |
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